1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Coluracetam

Coluracetam (Synonyms: MKC-231)

Cat. No.: HY-17553 Purity: 99.87%
Handling Instructions

Coluracetam(MKC-231) is a new choline uptake enhancer.

For research use only. We do not sell to patients.

Coluracetam Chemical Structure

Coluracetam Chemical Structure

CAS No. : 135463-81-9

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10 mM * 1 mL in DMSO USD 55 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Coluracetam

    Coluracetam purchased from MCE. Usage Cited in: J Pain Res. 2018 Sep 21;11:1971-1982.

    Immunoblots for CHT1 in the colon of WAS and WAS-MKC-231-treated rats reveal that the ratios of CHT1 to β-actin expression in WAS rats are considerably increased after 10 consecutive days of MKC-231 treatment.
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    Description

    Coluracetam(MKC-231) is a new choline uptake enhancer. IC50 value: Target: in vitro: MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding [1]. in vivo: Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested [2].

    Molecular Weight

    341.40

    Formula

    C₁₉H₂₃N₃O₃

    CAS No.
    SMILES

    O=C(NC1=C2C(OC(C)=C2C)=NC3=C1CCCC3)CN4C(CCC4)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 20 mg/mL (58.58 mM)

    H2O : 0.4 mg/mL (1.17 mM; Need ultrasonic and warming)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9291 mL 14.6456 mL 29.2912 mL
    5 mM 0.5858 mL 2.9291 mL 5.8582 mL
    10 mM 0.2929 mL 1.4646 mL 2.9291 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    ColuracetamMKC-231MKC231MKC 231iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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