135463-81-9
135463-81-9
Chemical Structure
Coluracetam
Synonym(s): MKC-231
- CAS No.: 135463-81-9
- Formula:C19H23N3O3
- Molecular Weight:341.40
IUPAC Name: N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide
InChIKey: PSPGQHXMUKWNDI-UHFFFAOYSA-N
SMILES: O=C(NC1=C2C(OC(C)=C2C)=NC3=C1CCCC3)CN4C(CCC4)=O
Biological Activity: Coluracetam (MKC-231) is an orally taken choline uptake enhancer. Coluracetam can improve the reduced acetylcholine levels in the hippocampus of rats and mice, enhancing learning difficulties, memory deficits, and cognitive impairments. Coluracetam induces a lower degree of hepatic venous hyperglycemia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Coluracetam | 99.87% | Coluracetam (MKC-231) is an orally taken choline uptake enhancer. Coluracetam can improve the reduced acetylcholine levels in the hippocampus of rats and mice, enhancing learning difficulties, memory deficits, and cognitive impairments. Coluracetam induces a lower degree of hepatic venous hyperglycemia. | ||||||||||||||||||||
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Coluracetam (Standard) | 99.96% | Coluracetam (Standard) is the analytical standard of Coluracetam. This product is intended for research and analytical applications. Coluracetam (MKC-231) is a new choline absorption enhancer. | ||||||||||||||||||||
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References
- [1]. Murai S, et al. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13. [Content Brief]
- [2]. Tomoko Bessho， et al. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. J Neural Transm (Vienna). 2008 Jul;115(7):1019-25. [Content Brief]
- [3]. K Uemura, et al. Central nervous system-mediated hyperglycemic effects of NIK-247, a cholinesterase inhibitor, and MKC-231, a choline uptake enhancer, in rats. Jpn J Pharmacol. 1999 Jan;79(1):113-5. [Content Brief]
