ChE/Aβ1-42-IN-1
ChE/Aβ1-42-IN-1 (compound 28) is a potent ChE and Aβ1-42 aggregation inhibitor with IC50s of 0.062, 0.767 and 1.227 µM for AChE, BuChE and Aβ1-42 aggregation, respectively. ChE/β1-42-IN-1 shows excellent BBB penetration. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer's agent.
For research use only. We do not sell to patients.
- CAS No.: 2761149-22-6
- Formula: C19H24N2O3
- Molecular Weight:328.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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AChE |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
6.3 μM
Compound: 28
|
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 35101650] |
Chemical Information
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CAS No. 2761149-22-6
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Molecular Weight 328.41
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Formula C19H24N2O3
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SMILES
COC1=C(C=C2C(N=C3CCCCC3=C2N4CCOCC4)=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)