1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. LY450108

LY450108 

Cat. No.: HY-10935 Purity: 99.51%
Handling Instructions

LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research.

For research use only. We do not sell to patients.

LY450108 Chemical Structure

LY450108 Chemical Structure

CAS No. : 376594-67-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 315 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 315 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 286 In-stock
Estimated Time of Arrival: December 31
10 mg USD 436 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1267 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
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Description

LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research[1][2][3][4].

In Vitro

AMPA receptors mediate most of the excitatory neurotransmission and play a key role in synaptic plasticity in the mammalian central nervous system (CNS). Recent evidence has shown that in addition to modulating fast synaptic plasticity and memory processes, AMPA receptor potentiators alter downstream signalling pathways and may thereby have utility in other CNS disorders.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.45

Formula

C₁₉H₂₂F₂N₂O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (126.12 mM)

H2O : 1 mg/mL (2.52 mM; Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6119 mL 25.2239 mL
5 mM 0.5045 mL 2.5224 mL 5.0448 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.51%

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Product Name:
LY450108
Cat. No.:
HY-10935
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