80373-22-4
Chemical Structure
Quinpirole
Synonym(s): LY 171555; (-)-LY 141865
- CAS No.: 80373-22-4
- Formula:C13H21N3
- Molecular Weight:219.33
IUPAC Name: (4aR,8aR)-5-propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline
InChIKey: FTSUPYGMFAPCFZ-ZWNOBZJWSA-N
SMILES: CCCN1[C@@]2([H])[C@@](CCC1)([H])CC3=C(C=NN3)C2
Biological Activity: Quinpirole (LY 171555; (-)-LY 141865) is a D2/D3 dopamine receptor agonist and a CaV1.3 calcium channel modulator. Quinpirole normalizes dendritic spine density in dopamine-depleted striatum, upregulates the protein expression of BCL2 and GluR2, downregulates the protein expression of BAX, and delays the onset of seizures. Quinpirole enhances learning and memory, inhibits neuronal apoptosis (apoptosis), and induces anxiety-like, stereotyped, and compulsive behaviors. Quinpirole disrupts prepulse inhibition in rhesus monkeys, enhances the activity of paraventricular thalamic neurons to promote recovery from Isoflurane anesthesia, and alters the composition of the gut microbiota in rats. Quinpirole can be used in research related to dyskinesia, pain, epilepsy, and neurological disorders including anxiety disorder, obsessive-compulsive disorder, and schizophrenia[1][2][3][4][5][6][7][8].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Quinpirole | 98.95% | Quinpirole (LY 171555; (-)-LY 141865) is a D2/D3 dopamine receptor agonist and a CaV1.3 calcium channel modulator. Quinpirole normalizes dendritic spine density in dopamine-depleted striatum, upregulates the protein expression of BCL2 and GluR2, downregulates the protein expression of BAX, and delays the onset of seizures. Quinpirole enhances learning and memory, inhibits neuronal apoptosis (apoptosis), and induces anxiety-like, stereotyped, and compulsive behaviors. Quinpirole disrupts prepulse inhibition in rhesus monkeys, enhances the activity of paraventricular thalamic neurons to promote recovery from Isoflurane anesthesia, and alters the composition of the gut microbiota in rats. Quinpirole can be used in research related to dyskinesia, pain, epilepsy, and neurological disorders including anxiety disorder, obsessive-compulsive disorder, and schizophrenia. | ||||||||||||||||||||
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- [1]. Collier TJ, et al. Quinpirole inhibits levodopa-induced dyskinesias at structural and behavioral levels: Efficacy negated by co-administration of isradipine. Exp Neurol. 2023;369:114522. [Content Brief]
- [2]. Mercado F, et al. Systemic quinpirole enhances tramadol analgesia in inflammatory pain, but not in neuropathic pain in male rats. Eur J Neurosci. 2024;60(12):7195-7210. [Content Brief]
- [3]. Wang H, et al. Neuroprotective effects of quinpirole on lithium chloride pilocarpine-induced epilepsy in rats and its underlying mechanisms. Eur J Med Res. 2024;29(1):121. Published 2024 Feb 14. [Content Brief]
- [4]. Fuller RW, et al. Decrease in hypothalamic epinephrine concentration and other neurochemical changes produced by quinpirole, a dopamine agonist, in rats. J Neural Transm. 1985;61(3-4):161-173. [Content Brief]
- [5]. Nabinger DD, et al. Long-lasting behavioral effects of quinpirole exposure on zebrafish. Neurotoxicol Teratol. 2021;88:107034. [Content Brief]
- [6]. Waguespack HF, et al. Quinpirole, but not muscimol, infused into the nucleus accumbens disrupts prepulse inhibition of the acoustic startle in rhesus macaques. Neuropharmacology. 2023;235:109563. [Content Brief]
- [7]. Ghuge S, et al. Multistrain probiotic rescinds quinpirole-induced obsessive-compulsive disorder phenotypes by reshaping of microbiota gut-brain axis in rats. Pharmacol Biochem Behav. 2023;232:173652. [Content Brief]
- [8]. Ao Y, et al. Application of quinpirole in the paraventricular thalamus facilitates emergence from isoflurane anesthesia in mice. Brain Behav. 2021;11(1):e01903. [Content Brief]
Keywords
