(+)-N-Allylnormetazocine hydrochloride
Based on 1 Customer Validation
(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease.
For research use only. We do not sell to patients.
- Purity: 99.6%
- CAS No.: 133005-41-1
- Formula: C17H24ClNO
- Molecular Weight:293.83
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
(+)-N-Allylnormetazocine hydrochloride (1 nM) inhibits µ, δ and κ opioid receptors of 28.5%, 2.5% and 31%, respectively[1]. (+)-N-Allylnormetazocine hydrochloride shows Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 133005-41-1
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Appearance Solid
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Molecular Weight 293.83
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Formula C17H24ClNO
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Color White to off-white
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SMILES
C[C@@]1(CCN2CC=C)C3=CC(O)=CC=C3C[C@@]2([H])C1([H])C.Cl
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Synonyms
(+)-SKF 10047 hydrochloride; (+)-N-Allyl-N-normetazocine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (340.33 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. May EL, et al. Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. J Med Chem. 2000 Dec 28;43(26):5030-6. [Content Brief]
[2]. Brady KT, et al. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science. 1982 Jan 8;215(4529):178-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4033 mL | 17.0166 mL | 34.0333 mL | 85.0832 mL |
| 5 mM | 0.6807 mL | 3.4033 mL | 6.8067 mL | 17.0166 mL | |
| 10 mM | 0.3403 mL | 1.7017 mL | 3.4033 mL | 8.5083 mL | |
| 15 mM | 0.2269 mL | 1.1344 mL | 2.2689 mL | 5.6722 mL | |
| 20 mM | 0.1702 mL | 0.8508 mL | 1.7017 mL | 4.2542 mL | |
| 25 mM | 0.1361 mL | 0.6807 mL | 1.3613 mL | 3.4033 mL | |
| 30 mM | 0.1134 mL | 0.5672 mL | 1.1344 mL | 2.8361 mL | |
| 40 mM | 0.0851 mL | 0.4254 mL | 0.8508 mL | 2.1271 mL | |
| 50 mM | 0.0681 mL | 0.3403 mL | 0.6807 mL | 1.7017 mL | |
| 60 mM | 0.0567 mL | 0.2836 mL | 0.5672 mL | 1.4181 mL | |
| 80 mM | 0.0425 mL | 0.2127 mL | 0.4254 mL | 1.0635 mL | |
| 100 mM | 0.0340 mL | 0.1702 mL | 0.3403 mL | 0.8508 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(+)-N-Allylnormetazocine hydrochloride Related Classifications
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