1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Sigma Receptor
    iGluR
  3. 4-PPBP maleate

4-PPBP maleate 

Cat. No.: HY-101043
Handling Instructions

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection.

For research use only. We do not sell to patients.

4-PPBP maleate Chemical Structure

4-PPBP maleate Chemical Structure

CAS No. : 201216-39-9

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Description

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

In Vitro

4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats weighing 300 to 385 g (Transient focal ischemia model)[2]
Dosage: 1 μmol/kg
Administration: Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion.
Result: Decreased brain injury after transient focal ischemia in rats.
Molecular Weight

409.52

Formula

C₂₅H₃₁NO₄

CAS No.
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4-PPBP maleate
Cat. No.:
HY-101043
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