1. GPCR/G Protein
  2. Sigma Receptor

BD1063 dhydrochloride 

Cat. No.: HY-18101A Purity: >98.0%
Data Sheet SDS Handling Instructions

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

For research use only. We do not sell to patients.
BD1063 dhydrochloride Chemical Structure

BD1063 dhydrochloride Chemical Structure

CAS No. : 206996-13-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $95 In-stock
25 mg $200 In-stock
50 mg $360 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

In Vivo

BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule[1]. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity[2]. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia[3].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.8892 mL 14.4459 mL 28.8917 mL
5 mM 0.5778 mL 2.8892 mL 5.7783 mL
10 mM 0.2889 mL 1.4446 mL 2.8892 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[1]

Rat: BD1063 is solubilized in isotonic saline and injected subcutaneously (s.c. 1 ml/kg), 15 min before testing. Rats are pretreated with BD1063 (0, 4.4, 7 and 11 mg/kg of body weight, free base weights, s.c.) using a within-subject Latin square design. sP rats: Rats are pretreated with BD1063 (0, 3, 4.4, 7 and 11 mg/kg of body weight, free base basis, s.c.) using a within-subject Latin square design[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

346.12

Formula

C₁₃H₂₀Cl₄N₂

CAS No.

206996-13-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BD1063 dhydrochloride
Cat. No.:
HY-18101A
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