1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
    Dopamine Receptor
  3. Rimcazole dihydrochloride

Rimcazole dihydrochloride (Synonyms: BW 234U dihydrochloride)

Cat. No.: HY-108510
Handling Instructions

Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can attenuate cocaine-induced locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.

For research use only. We do not sell to patients.

Rimcazole dihydrochloride Chemical Structure

Rimcazole dihydrochloride Chemical Structure

CAS No. : 75859-03-9

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Description

Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can attenuate cocaine-induced locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer[1][2][3][4].

IC50 & Target

sigma (σ) receptor[1]
dopamine transporter[1]

In Vitro

Rimcazole (1-50 μM; 24-48 h) concentration-dependently decreases the number HCT-116p53+/+ cells[2].
Rimcazole (50 μM; 1-24 h) dihydrochloride induces a transient accumulation of HIF-1α protei in cancer cells (HCT-116p53+/+ and MDA MB 231 cells) but not in normal human dermal fibroblasts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HCT-116p53+/+ cells
Concentration: 50 μM
Incubation Time: 1, 2, 3, 5, 6, 24 hours
Result: Accumulation of HIF-1α protein, maximal at 6 h.
No change in p53 protein levels.
HIF-1α protein levels returned to normal steady-state levels within 24 h.
Molecular Weight

394.38

Formula

C₂₁H₂₉Cl₂N₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Rimcazole dihydrochloride
Cat. No.:
HY-108510
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