75859-03-9
Chemical Structure
Rimcazole dihydrochloride
Synonym(s): BW 234U dihydrochloride
- CAS No.: 75859-03-9
- Formula:C21H29Cl2N3
- Molecular Weight:394.38
IUPAC Name: 9-(3-((3R,5S)-3,5-dimethylpiperazin-1-yl)propyl)-9H-carbazole dihydrochloride
InChIKey: ZWHRZGHGYMUSRM-VWDRLOGHSA-N
SMILES: [H]Cl.C[C@@H]1N[C@H](C)CN(CCCN2C3=C(C4=C2C=CC=C4)C=CC=C3)C1.[H]Cl
Biological Activity: Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer[1][2][3][4].
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Rimcazole dihydrochloride | 99.96% | Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer. | ||||||||||||||||||||
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Rimcazole dihydrochloride (Standard) | ≥98% | Rimcazole dihydrochloride (Standard) is the analytical standard of Rimcazole (dihydrochloride) (HY-108510). This product is intended for research and analytical applications. Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer. | ||||||||||||||||||||
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Similarity Score 0.97
HY-121813Rimcazole -
Similarity Score 0.97
HY-W800259trans-(3R)-Rimcazole -
Similarity Score 0.66
HY-W014334Carbazole-9-ethanol -
Similarity Score 0.64
HY-W0150039-Ethylcarbazole -
Similarity Score 0.59
HY-152215Dynamin IN-1 -
Similarity Score 0.59
HY-152216Dynamin IN-2 -
Similarity Score 0.56
HY-W011890Cridanimod -
Similarity Score 0.56
HY-113846ACMP-5 dihydrochloride -
Similarity Score 0.56
HY-108637APhiKan 083 hydrochloride -
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References
- [1]. Gilmore DL, et, al. Review of the pharmacological and clinical profile of rimcazole. CNS Drug Rev. Spring 2004;10(1):1-22. [Content Brief]
- [2]. Achison M, et, al. HIF-1alpha contributes to tumour-selective killing by the sigma receptor antagonist rimcazole. Oncogene. 2007 Feb 22;26(8):1137-46. [Content Brief]
- [3]. Matsumoto RR, et, al. Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology. 2001 Dec;41(7):878-86. [Content Brief]
- [4]. Job MO, et, al. A behavioral economic analysis of the effects of rimcazole on reinforcing effects of cocaine injection and food presentation in rats. Psychopharmacology (Berl). 2019 Dec;236(12):3601-3612. [Content Brief]
