1. Apoptosis
  2. MDM-2/p53

PhiKan 083 hydrochloride 

Cat. No.: HY-108637A Purity: >99.0%
Handling Instructions

PhiKan 083 hydrochloride is a carbazole derivative, which can stabilize Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR, used for cancer research.

For research use only. We do not sell to patients.

PhiKan 083 hydrochloride Chemical Structure

PhiKan 083 hydrochloride Chemical Structure

CAS No. : 1050480-30-2

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 300 Get quote
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of PhiKan 083 hydrochloride:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

PhiKan 083 hydrochloride is a carbazole derivative, which can stabilize Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR, used for cancer research.

IC50 & Target

Kd: 167 μM (T-p53C-Y220C)[1]

In Vitro

PhiKan 083 hydrochloride is a stabilizer of Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR. Analytical ultracentrifugation gives a Kd of 170 μM for PhiKan083, at 10°C. Isothermal titration of PhiKan083 with T-p53C-Y220C gives 1:1 stoichiometry and a Kd of 125 ± 10 μM[1]. PhiKan083 can binds with the cavity on the surface of Y220C-mutated p53[2].

Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (7.28 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6391 mL 18.1957 mL 36.3914 mL
5 mM 0.7278 mL 3.6391 mL 7.2783 mL
10 mM 0.3639 mL 1.8196 mL 3.6391 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

274.79

Formula

C₁₆H₁₉ClN₂

CAS No.

1050480-30-2

SMILES

CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
PhiKan 083 hydrochloride
Cat. No.:
HY-108637A
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PhiKan 083 hydrochloride

Cat. No.: HY-108637A