1050480-30-2
1050480-30-2
Chemical Structure
PhiKan 083 hydrochloride
- CAS No.: 1050480-30-2
- Formula:C16H19ClN2
- Molecular Weight:274.79
IUPAC Name: 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride
InChIKey: IXWVUPURFWFRNE-UHFFFAOYSA-N
SMILES: CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl
Biological Activity: PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3].
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PhiKan 083 hydrochloride | 99.27% | PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells. | ||||||||||||||||||||
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References
- [1]. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. [Content Brief]
- [3]. Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511. [Content Brief]
Keywords
