PhiKan 083 (Standard)
PhiKan 083 (Standard) is the analytical standard of PhiKan 083 (HY-108637). This product is intended for research and analytical applications. PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM. PhiKan 083 can be used for cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 880813-36-5
- Fòrmula: C16H18N2
- Peso molecular:238.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
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HY-108637
PhiKan 083MDM-2/p53 p53 Activator -
HY-18634
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HY-16702A
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HY-18343A
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HY-15676
IdasanutlinMDM2 Inhibitor -
HY-103640
Amifostine thiol dihydrochloridep53 Activator -
HY-16664
SJ-172550MDM-2/p53 MDM2 Inhibitor -
HY-15484
Pifithrin-α hydrobromidep53 Inhibitor -
HY-18935A
CBL0137 hydrochlorideNF-κB Inhibitor -
HY-B0639
AmifostineCytoprotective Agent -
HY-18935
CBL0137FACT Inhibitor
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 880813-36-5
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Peso molecular 238.33
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Fòrmula C16H18N2
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SMILES
CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. [Content Brief]
[2]. Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32(1):68-74. [Content Brief]
[3]. Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9(30):21495-21511. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PhiKan 083 (Standard) Related Classifications
HY-108637R Related Classifications
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