1. Apoptosis
  2. MDM-2/p53
  3. CP-31398 dihydrochloride

CP-31398 dihydrochloride 

Cat. No.: HY-18343A Purity: 99.16%
Handling Instructions

CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

For research use only. We do not sell to patients.

CP-31398 dihydrochloride Chemical Structure

CP-31398 dihydrochloride Chemical Structure

CAS No. : 1217195-61-3

Size Price Stock Quantity
5 mg USD 88 In-stock
Estimated Time of Arrival: December 31
10 mg USD 143 In-stock
Estimated Time of Arrival: December 31
25 mg USD 275 In-stock
Estimated Time of Arrival: December 31
50 mg USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 715 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53[1][2][3].

In Vitro

CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells[1].
CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Saos-2 cells expressing transfected mutant p53.
Concentration: 36.75 μM.
Incubation Time: 16 h.
Result: Induction of p21 in cells expressing only mutant p53.

Western Blot Analysis[3]

Cell Line: LN-18 and U87MG cells.
Concentration: 36 μM.
Incubation Time: 16 h.
Result: Decreased the levels of procaspase 3 and induced cleavage of caspase 7.
In Vivo

CP-31398 (100 mg/kg, orally) exhibits significant anti-tumor activity in mice models[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Small human tumor xenografts in mice[1].
Dosage: 100 mg/kg.
Administration: Orally twice daily for 7 days.
Result: Suppressed A375.S2 tumor growth by -50%.
Molecular Weight

435.39

Formula

C22H28Cl2N4O

CAS No.
SMILES

CN(C)CCCNC1=C2C=CC=CC2=NC(/C=C/C3=CC=C(OC)C=C3)=N1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (19.13 mM; ultrasonic and warming and heat to 65°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2968 mL 11.4840 mL 22.9679 mL
5 mM 0.4594 mL 2.2968 mL 4.5936 mL
10 mM 0.2297 mL 1.1484 mL 2.2968 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.83 mg/mL (1.91 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 0.83 mg/mL (1.91 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References
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Product Name:
CP-31398 dihydrochloride
Cat. No.:
HY-18343A
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