1. Apoptosis
  2. MDM-2/p53
  3. Pifithrin-β hydrobromide

Pifithrin-β hydrobromide (Synonyms: PFT β (hydrobromide))

Cat. No.: HY-16702A Purity: 99.90%
Handling Instructions

Pifithrin-β hydrobromide is a potent p53 inhibitor with an IC50 of 23 μM.

For research use only. We do not sell to patients.

Pifithrin-β hydrobromide Chemical Structure

Pifithrin-β hydrobromide Chemical Structure

CAS No. : 511296-88-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
5 mg USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 113 In-stock
Estimated Time of Arrival: December 31
50 mg USD 462 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Pifithrin-β hydrobromide:

Top Publications Citing Use of Products

Publications Citing Use of MCE Pifithrin-β hydrobromide

    Pifithrin-β hydrobromide purchased from MCE. Usage Cited in: PLoS One. 2018 Sep 20;13(9):e0203833.

    Western Blot analysis of TFDP3, p53 and LC3 in whole cell lysates of MDA-MB-231 transfected and treated with indicated plasmids and reagents. Cells in the treatment group are incubated with 20 μM PFT-beta for 24 hours.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    Pifithrin-β hydrobromide is a potent p53 inhibitor with an IC50 of 23 μM.

    IC50 & Target

    IC50: 23 μM (p53)[1]

    In Vitro

    Pifithrin-α hydrobromide, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

    Molecular Weight




    CAS No.





    Room temperature in continental US; may vary elsewhere

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 26 mg/mL (74.44 mM; Need ultrasonic and warming)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8630 mL 14.3148 mL 28.6295 mL
    5 mM 0.5726 mL 2.8630 mL 5.7259 mL
    10 mM 0.2863 mL 1.4315 mL 2.8630 mL
    *Please refer to the solubility information to select the appropriate solvent.
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