Pifithrin-α, p-Nitro, Cyclic
Based on 4 publication(s) in Google Scholar
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue.
For research use only. We do not sell to patients.
- Purity: 99.37%
- CAS No.: 60477-38-5
- Formula: C15H13N3O2S
- Molecular Weight:299.35
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Pifithrin-α, p-Nitro, Cyclic
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cortical neurone | ED50 |
30 nM
Compound: 4b
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Inhibition of etoposide-induced death of mouse E15.5 cortical neurones
Inhibition of etoposide-induced death of mouse E15.5 cortical neurones
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[PMID: 16759106] |
Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 60477-38-5
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Appearance Solid
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Molecular Weight 299.35
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Formula C15H13N3O2S
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Color Light yellow to yellow
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SMILES
O=[N+]([O-])C1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
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Synonyms
PFN-α
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 2 years; -20°C, 1 year (stored under nitrogen)
Publications (4)
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Journal Impact Factor
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Most Recent
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Phytomedicine
JinLiDa granules alleviates cardiac hypertrophy and inflammation in diabetic cardiomyopathy by regulating TP53. [Abstract]2024 May 10:130:155659. PMID: 38759318 -
Antioxidants (Basel)
Flt3 Activation Mitigates Mitochondrial Fragmentation and Heart Dysfunction through Rebalanced L-OPA1 Processing by Hindering the Interaction between Acetylated p53 and PHB2 in Cardiac Remodeling. [Abstract]2023 Aug 22;12(9):1657. PMID: 37759959 -
Biomolecules
High-Intensity Focused Ultrasound Decreases Subcutaneous Fat Tissue Thickness by Increasing Apoptosis and Autophagy. [Abstract]2023 Feb 18;13(2):392. PMID: 36830763 -
FASEB J
Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics. [Abstract]2022 Dec;36(12):e22672. PMID: 36440960
Solvent & Solubility
DMF : 12.5 mg/mL (41.76 mM; Need ultrasonic)
DMSO : 5 mg/mL (16.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Pietrancosta N, et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49(12):3645-52. [Content Brief]
[2]. Dinca EB, et al. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Res. 2008 Dec 15;68(24):10034-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (stored under nitrogen). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 3.3406 mL | 16.7029 mL | 33.4057 mL | 83.5143 mL |
| 5 mM | 0.6681 mL | 3.3406 mL | 6.6811 mL | 16.7029 mL | |
| 10 mM | 0.3341 mL | 1.6703 mL | 3.3406 mL | 8.3514 mL | |
| 15 mM | 0.2227 mL | 1.1135 mL | 2.2270 mL | 5.5676 mL | |
| DMF | 20 mM | 0.1670 mL | 0.8351 mL | 1.6703 mL | 4.1757 mL |
| 25 mM | 0.1336 mL | 0.6681 mL | 1.3362 mL | 3.3406 mL | |
| 30 mM | 0.1114 mL | 0.5568 mL | 1.1135 mL | 2.7838 mL | |
| 40 mM | 0.0835 mL | 0.4176 mL | 0.8351 mL | 2.0879 mL |
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