1. Apoptosis
  2. MDM-2/p53
  3. Pifithrin-α, p-Nitro, Cyclic

Pifithrin-α, p-Nitro, Cyclic (Synonyms: PFN-α)

Cat. No.: HY-123076 Purity: ≥98.0%
Handling Instructions

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue.

For research use only. We do not sell to patients.

Pifithrin-α, p-Nitro, Cyclic Chemical Structure

Pifithrin-α, p-Nitro, Cyclic Chemical Structure

CAS No. : 60477-38-5

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Based on 1 publication(s) in Google Scholar

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Description

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2].

In Vitro

Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM[1].
Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

299.35

Formula

C₁₅H₁₃N₃O₂S

CAS No.
SMILES

O=[N+]([O-])C1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMF : 12.5 mg/mL (41.76 mM; Need ultrasonic)

DMSO : 5 mg/mL (16.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3406 mL 16.7029 mL 33.4057 mL
5 mM 0.6681 mL 3.3406 mL 6.6811 mL
10 mM 0.3341 mL 1.6703 mL 3.3406 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥99.0%

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Keywords:

Pifithrin-α, p-Nitro, CyclicPFN-αMDM-2/p53celldeathneuronsp53-triggeredcorticalp21WAF1expressionposttranscriptionalInhibitorinhibitorinhibit

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Pifithrin-α, p-Nitro, Cyclic
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