1. Apoptosis
  2. MDM-2/p53
  3. Pifithrin-β

Pifithrin-β (Synonyms: PFT β; Cyclic Pifithrin-α)

Cat. No.: HY-16702
Handling Instructions

Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

For research use only. We do not sell to patients.

Pifithrin-β Chemical Structure

Pifithrin-β Chemical Structure

CAS No. : 60477-34-1

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Top Publications Citing Use of Products

    Pifithrin-β purchased from MCE. Usage Cited in: PLoS One. 2018 Sep 20;13(9):e0203833.

    Western Blot analysis of TFDP3, p53 and LC3 in whole cell lysates of MDA-MB-231 transfected and treated with indicated plasmids and reagents. Cells in the treatment group are incubated with 20 μM PFT-beta for 24 hours.
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    Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

    IC50 & Target

    IC50: 23 μM (p53)[1]

    In Vitro

    Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight




    CAS No.

    Room temperature in continental US; may vary elsewhere.


    Please store the product under the recommended conditions in the Certificate of Analysis.

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