NE-100 hydrochloride

Name: NE-100 hydrochloride
Brand: MedChemExpress
SKU: HY-101484A
Rating: 4.5 (1 reviews)

Cat. No.: HY-101484A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC₅₀ of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2].

For research use only. We do not sell to patients.

NE-100 hydrochloride Chemical Structure

CAS No. : 149409-57-4

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 195	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

391.97

Formula

C₂₃H₃₄ClNO₂

CAS No.

149409-57-4

Appearance

Solid

Color

White to light yellow

SMILES

CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (637.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (255.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5512 mL	12.7561 mL	25.5122 mL
5 mM	0.5102 mL	2.5512 mL	5.1024 mL
10 mM	0.2551 mL	1.2756 mL	2.5512 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (244 KB)

Handling Instructions (2659 KB)

References

[1]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9. [Content Brief]

[2]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.5512 mL	12.7561 mL	25.5122 mL	63.7804 mL
	5 mM	0.5102 mL	2.5512 mL	5.1024 mL	12.7561 mL
	10 mM	0.2551 mL	1.2756 mL	2.5512 mL	6.3780 mL
	15 mM	0.1701 mL	0.8504 mL	1.7008 mL	4.2520 mL
	20 mM	0.1276 mL	0.6378 mL	1.2756 mL	3.1890 mL
	25 mM	0.1020 mL	0.5102 mL	1.0205 mL	2.5512 mL
	30 mM	0.0850 mL	0.4252 mL	0.8504 mL	2.1260 mL
	40 mM	0.0638 mL	0.3189 mL	0.6378 mL	1.5945 mL
	50 mM	0.0510 mL	0.2551 mL	0.5102 mL	1.2756 mL
	60 mM	0.0425 mL	0.2126 mL	0.4252 mL	1.0630 mL
	80 mM	0.0319 mL	0.1595 mL	0.3189 mL	0.7973 mL
	100 mM	0.0255 mL	0.1276 mL	0.2551 mL	0.6378 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.