149409-57-4
149409-57-4
Chemical Structure
NE-100 hydrochloride
- CAS No.: 149409-57-4
- Formula:C23H34ClNO2
- Molecular Weight:391.97
IUPAC Name: N-(4-methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine hydrochloride
InChIKey: ZHGMDXSHODHWHV-UHFFFAOYSA-N
SMILES: CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.[H]Cl
Biological Activity: NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases[1][2][3].
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NE-100 hydrochloride | 99.1% | NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases. | ||||||||||||||||||||
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NE-100 hydrochloride (Standard) | ≥98% | NE-100 hydrochloride (Standard) is the analytical standard of NE-100 hydrochloride (HY-101484A). This product is intended for research and analytical applications. NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases. | ||||||||||||||||||||
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References
- [1]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9. [Content Brief]
- [2]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90. [Content Brief]
- [3]. Okuyama S, et al. Effect of NE-100, a novel sigma receptor ligand, on phencyclidine- induced delayed cognitive dysfunction in rats. Neurosci Lett. 1995 Apr 7;189(1):60-2. [Content Brief]
