1. GPCR/G Protein
  2. Sigma Receptor

4-IBP 

Cat. No.: HY-100155 Purity: >98.0%
Handling Instructions

4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .

For research use only. We do not sell to patients.

4-IBP Chemical Structure

4-IBP Chemical Structure

CAS No. : 155798-08-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 840 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) . IC50 value: 1.7 nM (Ki) Target: σ1 in vitro: 4-IBP is a σ1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells. 4-IBP is used to investigate whether targeting theσ1 receptor could modify in vitro the migration rates of human cancer cells and increase the sensitivity of metastasizing human A549 NSCLC cells and infiltrating human glioblastoma cells to cytotoxic insults of either proapoptotic or proautophagic drugs.[1] in vivo: 4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that were orthotopically grafted with invasive cancer cells.[1]

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3793 mL 11.8965 mL 23.7931 mL
5 mM 0.4759 mL 2.3793 mL 4.7586 mL
10 mM 0.2379 mL 1.1897 mL 2.3793 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

420.29

Formula

C₁₉H₂₁IN₂O

CAS No.

155798-08-6

SMILES

O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C(I)C=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
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Product Name:
4-IBP
Cat. No.:
HY-100155
Quantity:

4-IBP

Cat. No.: HY-100155