1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. PRE-084 hydrochloride

PRE-084 hydrochloride 

Cat. No.: HY-18100A Purity: 99.80%
Handling Instructions

PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.

For research use only. We do not sell to patients.

PRE-084 hydrochloride Chemical Structure

PRE-084 hydrochloride Chemical Structure

CAS No. : 75136-54-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
10 mg USD 75 In-stock
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50 mg USD 300 In-stock
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100 mg USD 550 In-stock
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200 mg USD 990 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    PRE-084 hydrochloride purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2020 Feb 28. 

    Chronic PRE-084 treatment alleviates DA neuron loss in Dicer cKO mice. TH and Iba1 immunostaining. Representative photomicrographs are shown at ×20 magnification (scale bars, 100 μm).
    • Biological Activity

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    • References

    • Customer Review

    Description

    PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay. IC50 value: 44 nM Target: sigma receptor in vitro: PRE-084 has an IC50 of more than 100,000 nM for PCP receptors and an IC50 higher than 10,000 nM in a variety of other receptor systems. [1] in vivo: PRE-084 improves motor neuron survival and motor performance in wobbler mice. PRE-084 enhances BDNF-mediated trophic support.[2]

    Molecular Weight

    353.88

    Formula

    C₁₉H₂₈ClNO₃

    CAS No.

    75136-54-8

    SMILES

    O=C(C1(C2=CC=CC=C2)CCCCC1)OCCN3CCOCC3.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 34 mg/mL (96.08 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8258 mL 14.1291 mL 28.2582 mL
    5 mM 0.5652 mL 2.8258 mL 5.6516 mL
    10 mM 0.2826 mL 1.4129 mL 2.8258 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (5.88 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (5.88 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (5.88 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.80%

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    Keywords:

    PRE-084PRE084PRE 084Sigma ReceptorInhibitorinhibitorinhibit

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    Product Name:
    PRE-084 hydrochloride
    Cat. No.:
    HY-18100A
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