201216-39-9
201216-39-9
Chemical Structure
4-PPBP maleate
- CAS No.: 201216-39-9
- Formula:C25H31NO4
- Molecular Weight:409.52
IUPAC Name: 4-phenyl-1-(4-phenylbutyl)piperidine maleate
InChIKey: OASPNIMFGJVLES-BTJKTKAUSA-N
SMILES: O=C(O)/C=C\C(O)=O.N1(CCCCC2=CC=CC=C2)CCC(C3=CC=CC=C3)CC1
Biological Activity: 4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-PPBP maleate | 99.63% | 4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection. | ||||||||||||||||||||
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L-693403 maleate | L-693403 maleate is a high affinity and selective σ ligand. L-693403 maleate has the potential for physiological disease research. | |||||||||||||||||||||
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4F 4PP oxalate | 98.86% | 4F 4PP (oxalate) is a selective 5-HT2A antagonist with almost as high affinity (Ki= 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki= 620 nM). | ||||||||||||||||||||
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Glemanserin | 98.96% | Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively). | ||||||||||||||||||||
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LY 88329 | LY 88329 is a potent narcotic antagonist. | |||||||||||||||||||||
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GBR 12935 fumarate | GBR 12935 fumarate is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 fumarate stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 fumarate also prevents the d-Fenfluramine-induced head-twitch response in mice. | |||||||||||||||||||||
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Ro 25-6981 Maleate | 99.25% | Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD). | ||||||||||||||||||||
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S1R agonist 1 | ≥98.0% | S1R agonist 1 (Compound 6b) is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity. | ||||||||||||||||||||
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S1R agonist 1 hydrochloride | 99.83% | S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity. | ||||||||||||||||||||
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S1R agonist 2 | ≥98.0% | S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity. | ||||||||||||||||||||
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N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride | N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride is structurally similar to known opioids. | |||||||||||||||||||||
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References
- [1]. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. [Content Brief]
- [2]. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. [Content Brief]
- [3]. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424. [Content Brief]
