2. Neuronal Signaling
  3. Sigma Receptor
  4. S1R agonist 2

S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity.

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S1R agonist 2 Chemical Structure

S1R agonist 2 Chemical Structure

CAS No. : 150085-21-5

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Based on 1 publication(s) in Google Scholar

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S1R agonist 2 Related Antibodies

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Description

S1R agonist 2 (Compound 8b) is a selective S1R agonist with Kis of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].

IC50 & Target[1]

Sigma 1 Receptor

1.1 nM (Ki)

Sigma 2 Receptor

88 nM (Ki)

In Vitro

S1R agonist 2 (Compound 8b; 0.1-5 μM) significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner[1].
S1R agonist 2 (24 h) significantly prevents cell damage induced by Rotenone (HY-B1756) when tested at the concentration of 1 μM in SHSY5Y cells[1].
S1R agonist 2 (0.1-5 μM; 24 h) demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells[1].
S1R agonist 2 (0-10 μM; 24-72 h) shows no cytotoxicity against A549, LoVo and Panc-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S1R agonist 2 Related Antibodies
In Vivo

S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) does not induce embryo death (100% of embryos alive) at 10 μM, but induces the death of all zebrafish embryo at the highest dose tested (50 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

309.45

Formula

C21H27NO
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

C1(OCCCN2CCC(CC2)CC3=CC=CC=C3)=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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S1R agonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S1R agonist 2150085-21-5Sigma ReceptorSHSY5YPC12Inhibitorinhibitorinhibit

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