L-Glutamic acid monosodium salt

Name: L-Glutamic acid monosodium salt
Brand: MedChemExpress
SKU: HY-14608A
Rating: 5.0 (14 reviews)

Cat. No.: HY-14608A Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases. L-Glutamic acid monosodium salt acts at ionotropic and metabotropic glutamate receptors.

For research use only. We do not sell to patients.

CAS No. : 142-47-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of L-Glutamic acid monosodium salt:

L-Glutamic acid In-stock
L-Glutamic acid monosodium salt (Standard) Get quote

14 Publications Citing Use of MCE L-Glutamic acid monosodium salt

Bio/Physico-chemical Assay

Flow Cytometry

Cell Proliferation/Viability Assay

RT-PCR

Cell Imaging/Staining

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 5:e11194. [Abstract]; L-Glutamic acid (100 µM; 10 min) for activation of spike count. Spontaneous LFP activity is recorded from OPAB that has been pre-treated with Bicuculline and stimulated with L-Glutamic acid. The LFP signal from the activated OPAB is measured (pre), and then the electrical signal is inhibited for 10 min using a cocktail of TTX, CNQX, and AP5 and LFP was recorded again (post).

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: Cancer Immunol Immunother. 2025 Jun 7;74(8):240. [Abstract]; Flow cytometry representative image showing the effect of exogenous glutamate (1 mM) on mouse primary T cells.

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; Viability of HT22 cells treated with Glutamate at different concentrations (0, 5, 10, 15, 20 and 25 mM) for 24 h (n=5 at each concentration).

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; The relative mRNA expression levels of c-fos in the control, glu (20 mM, 24 h) and lactate groups (n=6 in each group).

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; Fluorescence images of TUNEL staining of HT22 cells in the control, glu (20 mM, 24 h) and lactate groups.

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Inflamm Res. 2025 Jan 27:18:1235-1254. [Abstract]; Images of VGLUT1 fluorescence staining in HT22 cells from the control, glu (20 mM, 24 h) and lactate groups.

: L-Glutamic acid monosodium salt purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 18;22(1):178. [Abstract]; PC3 and DU145 cells were treated with 10 μM glutamate for 24 h, after which the protein expression levels were analysed by western blotting. The expression intensity was normalized to that of β-tubulin (right panel).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

AMPA Receptor

Human Endogenous Metabolite

In Vitro

L-Glutamic acid monosodium salt (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus^[3].
L-Glutamic acid monosodium salt (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	SH-SY5Y, IMR-32, SK-N-BE(2)
Concentration:	2, 5, 10, 20 mM
Incubation Time:	24 and 48 h
Result:	Reduced cell viability in a dose-dependent manner.

In Vivo

L-Glutamic acid monosodium salt (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice^[1].
L-Glutamic acid monosodium salt (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Crv4 mice model^[1]
Dosage:	3g/kg
Administration:	s.c., single dose
Result:	Reduced the number of Brn-3a⁺ RGCs by >70%. In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.

Animal Model:	CPF-induced rat model^[5]
Dosage:	750 mg/kg
Administration:	i.p.
Result:	Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.

Molecular Weight

169.11

Formula

C₅H₈NNaO₄

CAS No.

142-47-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CC[C@H](N)C(O)=O

Structure Classification

Amino acids

Initial Source

Animals

Microorganisms

mammalian brain

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (591.33 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9133 mL	29.5666 mL	59.1331 mL
5 mM	1.1827 mL	5.9133 mL	11.8266 mL
10 mM	0.5913 mL	2.9567 mL	5.9133 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (591.33 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (282 KB) SDS (393 KB)

COA (252 KB) HNMR (239 KB)

Handling Instructions (2659 KB)

References

[1]. Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1. [Content Brief]

[2]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7. [Content Brief]

[3]. Boga Pekmezekmek A, et al. L-Glutamic acid monosodium salt reduces the harmful effect of lithium on the development of Xenopus laevis embryos. Environ Sci Pollut Res Int. 2020 Nov;27(33):42124-42132. [Content Brief]

[4]. Croce N, et al. Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures. J Neurosci Methods. 2013 Jul 15;217(1-2):26-30. [Content Brief]

[5]. Salyha N, et al. Protective role of l-glutamic acid and l-cysteine in mitigation the chlorpyrifos-induced oxidative stress in rats. Environ Toxicol Pharmacol. 2018 Dec;64:155-163. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.9133 mL	29.5666 mL	59.1331 mL	147.8328 mL
	5 mM	1.1827 mL	5.9133 mL	11.8266 mL	29.5666 mL
	10 mM	0.5913 mL	2.9567 mL	5.9133 mL	14.7833 mL
	15 mM	0.3942 mL	1.9711 mL	3.9422 mL	9.8555 mL
	20 mM	0.2957 mL	1.4783 mL	2.9567 mL	7.3916 mL
	25 mM	0.2365 mL	1.1827 mL	2.3653 mL	5.9133 mL
	30 mM	0.1971 mL	0.9856 mL	1.9711 mL	4.9278 mL
	40 mM	0.1478 mL	0.7392 mL	1.4783 mL	3.6958 mL
	50 mM	0.1183 mL	0.5913 mL	1.1827 mL	2.9567 mL
	60 mM	0.0986 mL	0.4928 mL	0.9856 mL	2.4639 mL
	80 mM	0.0739 mL	0.3696 mL	0.7392 mL	1.8479 mL
	100 mM	0.0591 mL	0.2957 mL	0.5913 mL	1.4783 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.