2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. ASP2535

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.

For research use only. We do not sell to patients.

ASP2535 Chemical Structure

ASP2535 Chemical Structure

CAS No. : 374886-51-8

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10 mM * 1 mL in DMSO USD 484 In-stock
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Based on 1 publication(s) in Google Scholar

ASP2535 Related Antibodies

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Description

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1].

IC50 & Target

GlyT1[1]
In Vitro

ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ASP2535 Related Antibodies
In Vivo

ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice[1].
ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-week-old male ddY mice[1]
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Significantly attenuated the MK-801-induced decrease in alternation rate.
Molecular Weight

382.42

Formula

C22H18N6O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C1=NN=C(C2=CC=C(C3=CC=CC=C3)N=C2)N1C4=CC=CC5=NON=C54)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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ASP2535 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASP2535374886-51-8ASP 2535ASP-2535GlyTGlycine transportersschizophreniaAlzheimerglycine transporter-1GlyT1Inhibitorinhibitorinhibit

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