1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. ASP2535

ASP2535 

Cat. No.: HY-110176
Handling Instructions

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.

For research use only. We do not sell to patients.

ASP2535 Chemical Structure

ASP2535 Chemical Structure

CAS No. : 374886-51-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 484 In-stock
Estimated Time of Arrival: December 31
5 mg USD 575 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1].

IC50 & Target

GlyT1[1]

In Vitro

ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro[1].

In Vivo

ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice[1].
ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats[1].

Animal Model: 5-week-old male ddY mice[1]
Dosage: 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration: Oral administration
Result: Significantly attenuated the MK-801-induced decrease in alternation rate.
Molecular Weight

382.42

Formula

C₂₂H₁₈N₆O

CAS No.

374886-51-8

SMILES

CC(C1=NN=C(C2=CC=C(C3=CC=CC=C3)N=C2)N1C4=CC=CC5=NON=C54)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ASP2535ASP 2535ASP-2535GlyTGlycine transportersschizophreniaAlzheimerglycine transporter-1GlyT1Inhibitorinhibitorinhibit

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ASP2535
Cat. No.:
HY-110176
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