1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. NFPS

NFPS 

Cat. No.: HY-107526
Handling Instructions

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.

For research use only. We do not sell to patients.

NFPS Chemical Structure

NFPS Chemical Structure

CAS No. : 405225-21-0

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Description

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].

IC50 & Target[1]

hGlyT1

2.8 nM (IC50)

rGlyT1

9.8 nM (IC50)

Molecular Weight

393.45

Formula

C₂₄H₂₄FNO₃

CAS No.

405225-21-0

SMILES

OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

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