1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. (Rac)-ALX 5407

(Rac)-ALX 5407  (Synonyms: (Rac)-NFPS)

Cat. No.: HY-107526
Handling Instructions

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion.

For research use only. We do not sell to patients.

(Rac)-ALX 5407 Chemical Structure

(Rac)-ALX 5407 Chemical Structure

CAS No. : 405225-21-0

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Description

NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].

IC50 & Target[1]

hGlyT1

2.8 nM (IC50)

rGlyT1

9.8 nM (IC50)

Molecular Weight

393.45

Formula

C24H24FNO3

CAS No.
SMILES

OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(Rac)-ALX 5407
Cat. No.:
HY-107526
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