405225-21-0
405225-21-0
Chemical Structure
(Rac)-ALX 5407
Synonym(s): (Rac)-NFPS
- CAS No.: 405225-21-0
- Formula:C24H24FNO3
- Molecular Weight:393.45
IUPAC Name: N-(3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)-N-methylglycine
InChIKey: FDORQEIHOKEJNX-UHFFFAOYSA-N
SMILES: OC(CN(C)CCC(C1=CC=C(F)C=C1)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
Biological Activity: NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively[1]. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion[2].
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(Rac)-ALX 5407 | NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively. NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. | |||||||||||||||||||||
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References
- [1]. Mallorga PJ, et al. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine. Neuropharmacology. 2003 Oct;45(5):585-93. [Content Brief]
- [2]. Huang B, et al. GlyT1 Inhibitor NFPS Exerts Neuroprotection via GlyR Alpha1 Subunit in the Rat Model of Transient Focal Cerebral Ischaemia and Reperfusion. Cell Physiol Biochem. 2016;38(5):1952-62. [Content Brief]
Keywords
