2. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  3. GlyT
    Endogenous Metabolite
  4. N-Arachidonylglycine

N-Arachidonylglycine  (Synonyms: NA-Gly)

Cat. No.: HY-103332 Purity: 98.82%
COA Handling Instructions

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

For research use only. We do not sell to patients.

N-Arachidonylglycine Chemical Structure

N-Arachidonylglycine Chemical Structure

CAS No. : 179113-91-8

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5 mg USD 55 In-stock
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10 mg USD 94 In-stock
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25 mg USD 209 In-stock
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50 mg USD 308 In-stock
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100 mg USD 506 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration[1][2].

IC50 & Target

GlyT2

5.1 μM (IC50)

In Vitro

N-Arachidonylglycine (0.1 nM-100 µM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells[1].
N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293-GPR18 cells
Concentration: 0.1 nM-100 µM
Incubation Time: 5 min
Result: Drove MAPK activation.
In Vivo

N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold[3].
N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[3]
Dosage: 10 mg/kg
Administration: Oral
Result: Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.
Animal Model: Mouse (peritonitis model)[3]
Dosage: 1.2 mg/kg
Administration: Oral; once
Result: Resulted in a significant 70% reduction of peritoneal cells.
Molecular Weight

361.52

Appearance

Oil

Formula

C22H35NO3
CAS No.
SMILES

O=C(O)CNC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (138.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7661 mL 13.8305 mL 27.6610 mL
5 mM 0.5532 mL 2.7661 mL 5.5322 mL
10 mM 0.2766 mL 1.3830 mL 2.7661 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.92 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

N-Arachidonylglycine179113-91-8NA-GlyGlyTEndogenous MetaboliteGlycine transportersendocannabinoidanandamideAEAGLYT2endometrialInhibitorinhibitorinhibit

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