1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. GlyT
    Endogenous Metabolite
  3. N-Arachidonylglycine

N-Arachidonylglycine (Synonyms: NA-Gly)

Cat. No.: HY-103332 Purity: ≥98.0%
Handling Instructions

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

For research use only. We do not sell to patients.

N-Arachidonylglycine Chemical Structure

N-Arachidonylglycine Chemical Structure

CAS No. : 179113-91-8

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Description

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration[1][2].

IC50 & Target

GlyT2

5.1 μM (IC50)

In Vitro

N-Arachidonylglycine (0.1 nM-100 µM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells[1].
N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293-GPR18 cells
Concentration: 0.1 nM-100 µM
Incubation Time: 5 min
Result: Drove MAPK activation.
In Vivo

N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold[3].
N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[3]
Dosage: 10 mg/kg
Administration: Oral
Result: Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.
Animal Model: Mouse (peritonitis model)[3]
Dosage: 1.2 mg/kg
Administration: Oral; once
Result: Resulted in a significant 70% reduction of peritoneal cells.
Molecular Weight

361.52

Formula

C₂₂H₃₅NO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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N-Arachidonylglycine
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