ALX-1393
ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.
Both the free form and hydrochloride salt form of the compound are susceptible to instability. It is recommended to opt for the stable trifluoroacetic acid (TFA) salt form (ALX-1393 TFA), which maintains equivalent biological activity.
For research use only. We do not sell to patients.
- CAS No.: 949164-09-4
- Formula: C23H22FNO4
- Molecular Weight:395.42
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-10809
Bitopertin -
HY-100416A
LY2365109 hydrochlorideGlyT1 Inhibitor -
HY-10809R
Bitopertin (Standard) -
HY-110176
ASP2535GlyT1 Inhibitor -
HY-112432
GlyT1 Inhibitor 1 -
HY-10809A
Bitopertin (R enantiomer)GlyT Inhibitor -
HY-10716A
PF-03463275GlyT1 Inhibitor -
HY-100416AR
LY2365109 hydrochloride (Standard)GlyT1 Inhibitor -
HY-100416
LY2365109GlyT1 Inhibitor -
HY-122666
Org 25935GlyT1 Inhibitor -
HY-107526
(Rac)-ALX 5407GlyT Inhibitor -
HY-10715
SSR504734GlyT1 Inhibitor
Biological Activity
Description
IC50 & Target
[1]|
GlyT2 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
21.1 nM
Compound: ALX1393
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Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
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[PMID: 19013063] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 949164-09-4
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Appearance Solid
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Molecular Weight 395.42
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Formula C23H22FNO4
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Color White to off-white
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SMILES
N[C@@H](COC(C1=CC=CC(F)=C1)C2=CC=CC=C2OCC3=CC=CC=C3)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21. [Content Brief]
[2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALX-1393 Related Classifications
HY-111029 Related Classifications
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