1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GlyT
  3. ALX-1393

ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.

Both the free form and hydrochloride salt form of the compound are susceptible to instability. It is recommended to opt for the stable trifluoroacetic acid (TFA) salt form (ALX-1393 TFA), which maintains equivalent biological activity.

For research use only. We do not sell to patients.

ALX-1393 Chemical Structure

ALX-1393 Chemical Structure

CAS No. : 949164-09-4

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Description

ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

IC50 & Target[1]

GlyT2

 

In Vivo

ALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

395.42

Formula

C23H22FNO4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](COC(C1=CC=CC(F)=C1)C2=CC=CC=C2OCC3=CC=CC=C3)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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ALX-1393 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
ALX-1393
Cat. No.:
HY-111029
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