ALX-1393 TFA
Based on 1 Customer Validation
ALX-1393 TFA, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.
For research use only. We do not sell to patients.
- Purity: 99.83%
- Formula: C25H23F4NO6
- Molecular Weight:509.45
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Neuronal Signaling Compound Library
HY-L013
Biological Activity
ALX1393 TFA (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 509.45
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Formula C25H23F4NO6
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Color White to off-white
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SMILES
N[C@@H](COC(C1=CC=CC(F)=C1)C2=CC=CC=C2OCC3=CC=CC=C3)C(O)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (196.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21. [Content Brief]
[2]. Takahashi Y, et al. Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain. Pharmacol Biochem Behav. 2015 Mar;130:46-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9629 mL | 9.8145 mL | 19.6290 mL | 49.0725 mL |
| 5 mM | 0.3926 mL | 1.9629 mL | 3.9258 mL | 9.8145 mL | |
| 10 mM | 0.1963 mL | 0.9815 mL | 1.9629 mL | 4.9073 mL | |
| 15 mM | 0.1309 mL | 0.6543 mL | 1.3086 mL | 3.2715 mL | |
| 20 mM | 0.0981 mL | 0.4907 mL | 0.9815 mL | 2.4536 mL | |
| 25 mM | 0.0785 mL | 0.3926 mL | 0.7852 mL | 1.9629 mL | |
| 30 mM | 0.0654 mL | 0.3272 mL | 0.6543 mL | 1.6358 mL | |
| 40 mM | 0.0491 mL | 0.2454 mL | 0.4907 mL | 1.2268 mL | |
| 50 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9815 mL | |
| 60 mM | 0.0327 mL | 0.1636 mL | 0.3272 mL | 0.8179 mL | |
| 80 mM | 0.0245 mL | 0.1227 mL | 0.2454 mL | 0.6134 mL | |
| 100 mM | 0.0196 mL | 0.0981 mL | 0.1963 mL | 0.4907 mL |
ALX-1393 TFA Related Classifications
HY-111029A Related Classifications
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