New cyclic tetrapeptides from Nonomuraea sp. TA-0426 that inhibit glycine transporter type 1 (GlyT1)

  • Bioorg Med Chem Lett. 2008 Dec 15;18(24):6321-3. doi: 10.1016/j.bmcl.2008.10.104.
Yuichi Terui  1 ,  Yi-wen Chu ,  Jun-ying Li ,  Tsutomu Ando ,  Takuya Fukunaga ,  Takeshi Aoki ,  Yoshihisa Toda
Affiliations
  • 1. Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan. [email protected]
PMID: 19013063 DOI: 10.1016/j.bmcl.2008.10.104
Abstract

In the course of our search for natural antipsychotic agents, we isolated five new cyclic tetrapeptides from the fermentation broth of Nonomuraea sp. TA-0426. These compounds turned out to be analogues of WSS2220, which had been produced by the same actinomycete and showed strong inhibitory activity against GlyT1. Four of the present peptides exhibit more potent GlyT1 inhibitory activities than WSS2220.