1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT

GlyT1 Inhibitor 1 

Cat. No.: HY-112432
Handling Instructions

GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1. Antipsychotic activity.

For research use only. We do not sell to patients.

GlyT1 Inhibitor 1 Chemical Structure

GlyT1 Inhibitor 1 Chemical Structure

CAS No. : 1820934-93-7

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].

IC50 & Target

rGlyT1

38 nM (IC50)

In Vivo

GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5811 mL 12.9056 mL 25.8111 mL
5 mM 0.5162 mL 2.5811 mL 5.1622 mL
10 mM 0.2581 mL 1.2906 mL 2.5811 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

387.43

Formula

C₂₂H₂₁N₅O₂

CAS No.

1820934-93-7

SMILES

CC(C)OC1=C(C(N2CC3=CN(C4=CC(C)=NC=C4)N=C3C2)=O)C=C(C#N)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GlyT1 Inhibitor 1
Cat. No.:
HY-112432
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GlyT1 Inhibitor 1

Cat. No.: HY-112432