1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. Iclepertin

Iclepertin (Synonyms: BI-425809)

Cat. No.: HY-138935 Purity: 99.65%
Handling Instructions

Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research.

For research use only. We do not sell to patients.

Iclepertin Chemical Structure

Iclepertin Chemical Structure

CAS No. : 1421936-85-7

Size Price Stock Quantity
5 mg USD 760 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 7200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research[1].

IC50 & Target[1]

GLT1

5.2 mM (IC50, In rat primary neurons )

GLT1

5 nM (IC50, In human SK-N-MC cells)

In Vitro

Iclepertin inhibits GlyT1 with the IC50 values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Single oral administration of Iclepertin induced a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels. Oral administration of Iclepertin in rats induced a dose‐dependent increase of glycine CSF levels from 30% (0.2 mg/kg, not significant) to 78% (2 mg/kg), relative to vehicle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

512.42

Formula

C20H18F6N2O5S

CAS No.
SMILES

O=C(C1=C(C=CC(S(C)(=O)=O)=C1)O[[email protected]](C)C(F)(F)F)N2C[[email protected]]3(C4=NOC(C(F)(F)F)=C4)[[email protected]@](C2)([H])C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 11.36 mg/mL (22.17 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9515 mL 9.7576 mL 19.5152 mL
5 mM 0.3903 mL 1.9515 mL 3.9030 mL
10 mM 0.1952 mL 0.9758 mL 1.9515 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Iclepertin
Cat. No.:
HY-138935
Quantity:
MCE Japan Authorized Agent: