1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. BI-425809

BI-425809 

Cat. No.: HY-138935
Handling Instructions

BI-425809 is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. BI-425809 is inactive against GlyT2. BI-425809 can be used for Alzheimer disease and schizophrenia research.

For research use only. We do not sell to patients.

BI-425809 Chemical Structure

BI-425809 Chemical Structure

CAS No. : 1421936-85-7

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Description

BI-425809 is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. BI-425809 is inactive against GlyT2. BI-425809 can be used for Alzheimer disease and schizophrenia research[1].

IC50 & Target[1]

GLT1

5.2 mM (IC50, In rat primary neurons )

GLT1

5 nM (IC50, In human SK-N-MC cells)

In Vitro

BI 425809 inhibits GlyT1 with the IC50 values of 5.2 nM in rat primary neurons and 5.0 nM in human SK-N-MC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Single oral administration of BI 425809 induced a dose-dependent increase of glycine cerebrospinal fluid (CSF) levels. Oral administration of BI-425809 in rats induced a dose‐dependent increase of glycine CSF levels from 30% (0.2 mg/kg, not significant) to 78% (2 mg/kg), relative to vehicle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.42

Formula

C₂₀H₁₈F₆N₂O₅S

CAS No.
SMILES

O=C(C1=C(C=CC(S(C)(=O)=O)=C1)O[[email protected]](C)C(F)(F)F)N2C[[email protected]]3(C4=NOC(C(F)(F)F)=C4)[[email protected]@](C2)([H])C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BI-425809BI425809BI 425809GlyTGlycine transportersGlyT1AlzheimerdiseaseschizophreniaInhibitorinhibitorinhibit

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HY-138935
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