1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. LY2365109 hydrochloride

LY2365109 hydrochloride 

Cat. No.: HY-100416A Purity: 99.32%
Handling Instructions

LY2365109 is a potent and selective GlyT1 inhibitors with IC50 value of 15.8 nM.

For research use only. We do not sell to patients.

LY2365109 hydrochloride Chemical Structure

LY2365109 hydrochloride Chemical Structure

CAS No. : 1779796-27-8

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
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100 mg USD 1260 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

LY2365109 is a potent and selective GlyT1 inhibitors with IC50 value of 15.8 nM. target: GlyT1[1] IC 50: 15.8 nM [1] In vivo: The reference for LY2365109 is 0.3 or 30 mg/kg by PO. LY2365109 appeared slightly more potent than ALX5407 over the dose-range tested on CSF levels of glycine in the rat LY2365109 can act to potentiate NMDA function in the PFC but also mediate sustained inhibition of GlyT1 transporters in caudal areas of the brain.[1] LY2365109 increased seizure thresholds in mice. Importantly, chronic seizures in the mouse model of TLE were robustly suppressed by systemic administration of the GlyT1 inhibitor LY2365109. [2]

Molecular Weight

421.91

Formula

C₂₂H₂₈ClNO₅

CAS No.

1779796-27-8

SMILES

O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (73.48 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3702 mL 11.8509 mL 23.7017 mL
5 mM 0.4740 mL 2.3702 mL 4.7403 mL
10 mM 0.2370 mL 1.1851 mL 2.3702 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product name:
LY2365109 hydrochloride
Cat. No.:
HY-100416A
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