1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GlyT
  3. LY2365109 hydrochloride

LY2365109 hydrochloride 

Cat. No.: HY-100416A Purity: 99.32%
Handling Instructions

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.

For research use only. We do not sell to patients.

LY2365109 hydrochloride Chemical Structure

LY2365109 hydrochloride Chemical Structure

CAS No. : 1779796-27-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 180 In-stock
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50 mg USD 720 In-stock
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100 mg USD 1260 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].

IC50 & Target

hGlyT1

15.8 nM nM (IC50)

In Vivo

LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine[1].
LY2365109 hydrochloride increases seizure thresholds in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (250-300 g)[1]
Dosage: 0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Oral administration
Result: Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.
Molecular Weight

421.91

Formula

C₂₂H₂₈ClNO₅

CAS No.

1779796-27-8

SMILES

O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (73.48 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3702 mL 11.8509 mL 23.7017 mL
5 mM 0.4740 mL 2.3702 mL 4.7403 mL
10 mM 0.2370 mL 1.1851 mL 2.3702 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LY2365109LY 2365109LY-2365109GlyTGlycine transportersHumanneuroblastomaglycineuptakeseizureInhibitorinhibitorinhibit

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Product Name:
LY2365109 hydrochloride
Cat. No.:
HY-100416A
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