1779796-27-8
1779796-27-8
Chemical Structure
LY2365109 hydrochloride
- CAS No.: 1779796-27-8
- Formula:C22H28ClNO5
- Molecular Weight:421.91
IUPAC Name: N-(2-(4-(benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)-N-methylglycine hydrochloride
InChIKey: ZQVOAGQZHDAFRM-UHFFFAOYSA-N
SMILES: O=C(O)CN(CCOC1=CC=C(C2=CC=C(OCO3)C3=C2)C=C1C(C)(C)C)C.Cl[H]
Biological Activity: LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a[1][2].
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LY2365109 hydrochloride | 98.69% | LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. | ||||||||||||||||||||
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LY2365109 hydrochloride (Standard) | ≥98% | LY2365109 (hydrochloride) (Standard) is the analytical standard of LY2365109 (hydrochloride) (HY-100416A). This product is intended for research and analytical applications. LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. | ||||||||||||||||||||
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References
- [1]. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54. [Content Brief]
- [2]. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65. [Content Brief]
