2. Immunology/Inflammation
  3. NO Synthase
  4. DETA NONOate

DETA NONOate  (Synonyms: Diethylamine NONOate; NOC-18)

Cat. No.: HY-136278 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting.

For research use only. We do not sell to patients.

DETA NONOate Chemical Structure

DETA NONOate Chemical Structure

CAS No. : 146724-94-9

Size Price Stock Quantity
5 mg USD 77 In-stock
10 mg USD 120 In-stock
50 mg USD 420 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

DETA NONOate Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting[1][2].

In Vitro

DETA NONOate (100 μM; 16 h) induces growth in an Mycobacterium abscessus complex (MABC) R morphotype by reduced glycopeptidolipid (GPL) expression of M. abscessus subspecies abscessus (Mab)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DETA NONOate Related Antibodies
In Vivo

DETA NONOate (15-150 μg/rat, i.c.v., once) exhibits a nociceptive effect in the rat formalin model[2].
DETA NONOate (1 µM) reduces ischemia- or ischemia/reperfusion-induced injury to cardiac mitochondria and prevents apoptotic cell death[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (Sixty-two, male, 200-250 g)[2]
Dosage: 15 or 150 μg per rat
Administration: i.c.v., once
Result: Accelerated the nociception in a dose-dependent manner, and this acceleration was completely abolished by Methylene Blue (HY-14536).
Molecular Weight

163.18

Formula

C4H13N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=NN(O)N(CCN)CCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (306.41 mM; ultrasonic and adjust pH to 9 with H2O)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.1282 mL 30.6410 mL 61.2820 mL
5 mM 1.2256 mL 6.1282 mL 12.2564 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (245 KB) HNMR (396 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.1282 mL 30.6410 mL 61.2820 mL 153.2051 mL
5 mM 1.2256 mL 6.1282 mL 12.2564 mL 30.6410 mL
10 mM 0.6128 mL 3.0641 mL 6.1282 mL 15.3205 mL
15 mM 0.4085 mL 2.0427 mL 4.0855 mL 10.2137 mL
20 mM 0.3064 mL 1.5321 mL 3.0641 mL 7.6603 mL
25 mM 0.2451 mL 1.2256 mL 2.4513 mL 6.1282 mL
30 mM 0.2043 mL 1.0214 mL 2.0427 mL 5.1068 mL
40 mM 0.1532 mL 0.7660 mL 1.5321 mL 3.8301 mL
50 mM 0.1226 mL 0.6128 mL 1.2256 mL 3.0641 mL
60 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5534 mL
80 mM 0.0766 mL 0.3830 mL 0.7660 mL 1.9151 mL
100 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5321 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DETA NONOate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DETA NONOate146724-94-9Diethylamine NONOate NOC-18NOC18NOC 18NOC-18NO SynthaseNitric oxide synthasesNOSexogenous nitric oxideneuroprotective effectNO-releasing compoundsMethylene blueNociceptionFormalin pain modelM. abscessus subspecies abscessusheart ischemiaInhibitorinhibitorinhibit

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