2. Immunology/Inflammation
  3. NO Synthase
  4. DETA NONOate

DETA NONOate  (Synonyms: Diethylamine NONOate; NOC-18)

Cat. No.: HY-136278 Purity: 98.10%
COA
SDS
Handling Instructions Technical Support

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting.

For research use only. We do not sell to patients.

CAS No. : 146724-94-9

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 8 publication(s) in Google Scholar

DETA NONOate Related Antibodies

Top Publications Citing Use of Products

    DETA NONOate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253.  [Abstract]

    NO donor DETA NONOate (100 μM) restored NO activity and substantially improved motility of BMDC.

    DETA NONOate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Nov 5:1006:178190.  [Abstract]

    The NO donor DETA NONOate (DETA-NO) (100 μM; 30 min) synergistically enhanced the ability of HEC95468 to stimulate cGMP production in CHO-Kl-Rat sGC cells, with an EC50 of 0.133 μM.

    DETA NONOate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 May 17:e2401269.  [Abstract]

    mRNA levels of CAF markers, pro-tumor factors, and immune-modulatory factors were analyzed by qPCR in the CAFs with hydrogen treatment followed by DETA NONOate (DETA/NO) (100–500 μM) treatment.

    DETA NONOate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2024 Nov;28(21):e70203.  [Abstract]

    DETA NONOate (20 μM; 24 h) significantly upregulated PROM1, ALDH1, POU5F1 and SOX2 mRNA expressions in non-CSCs.

    DETA NONOate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2024 Nov;28(21):e70203.  [Abstract]

    DETA NONOate (20 μM) induced S-nitrosylation of Notch1 and elevated binding of Notch1 to UCHL1 in CSCs.

    View All NO Synthase Isoform Specific Products:

    View All Isoforms
    nNOS iNOS eNOS

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting[1][2].

    In Vitro

    DETA NONOate (100 μM; 16 h) induces growth in an Mycobacterium abscessus complex (MABC) R morphotype by reduced glycopeptidolipid (GPL) expression of M. abscessus subspecies abscessus (Mab)[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    DETA NONOate Related Antibodies
    In Vivo

    DETA NONOate (15-150 μg/rat, i.c.v., once) exhibits a nociceptive effect in the rat formalin model[2].
    DETA NONOate (1 µM) reduces ischemia- or ischemia/reperfusion-induced injury to cardiac mitochondria and prevents apoptotic cell death[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Sprague-Dawley rats (Sixty-two, male, 200-250 g)[2]
    Dosage: 15 or 150 μg per rat
    Administration: i.c.v., once
    Result: Accelerated the nociception in a dose-dependent manner, and this acceleration was completely abolished by Methylene Blue (HY-14536).
    Molecular Weight

    163.18

    Formula

    C4H13N5O2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=NN(O)N(CCN)CCN
    Shipping

    Shipping with dry ice.
    Storage

    -80°C
    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (306.41 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.1282 mL 30.6410 mL 61.2820 mL
    5 mM 1.2256 mL 6.1282 mL 12.2564 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.10%

    SDS (394 KB)

    COA (245 KB) RP-HPLC (247 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 6.1282 mL 30.6410 mL 61.2820 mL 153.2051 mL
    5 mM 1.2256 mL 6.1282 mL 12.2564 mL 30.6410 mL
    10 mM 0.6128 mL 3.0641 mL 6.1282 mL 15.3205 mL
    15 mM 0.4085 mL 2.0427 mL 4.0855 mL 10.2137 mL
    20 mM 0.3064 mL 1.5321 mL 3.0641 mL 7.6603 mL
    25 mM 0.2451 mL 1.2256 mL 2.4513 mL 6.1282 mL
    30 mM 0.2043 mL 1.0214 mL 2.0427 mL 5.1068 mL
    40 mM 0.1532 mL 0.7660 mL 1.5321 mL 3.8301 mL
    50 mM 0.1226 mL 0.6128 mL 1.2256 mL 3.0641 mL
    60 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5534 mL
    80 mM 0.0766 mL 0.3830 mL 0.7660 mL 1.9151 mL
    100 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5321 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    DETA NONOate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DETA NONOate146724-94-9Diethylamine NONOate NOC-18NOC18NOC 18NOC-18NO SynthaseNitric oxide synthasesNOSexogenous nitric oxideneuroprotective effectNO-releasing compoundsMethylene blueNociceptionFormalin pain modelM. abscessus subspecies abscessusheart ischemiaInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    DETA NONOate
    Cat. No.:
    HY-136278
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (394 KB) Français - FR (394 KB) Deutsch - DE (394 KB) Norwegian - NO (394 KB) Español - ES (394 KB) Swedish - SV (394 KB) Italian - IT (394 KB) Korean - KR (394 KB) Portuguese - PT (394 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.