1. Immunology/Inflammation
  2. NO Synthase
  3. S-Nitroso-N-acetyl-DL-penicillamine

S-Nitroso-N-acetyl-DL-penicillamine (Synonyms: SNAP)

Cat. No.: HY-121526 Purity: >98.0%
Handling Instructions

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation.

For research use only. We do not sell to patients.

S-Nitroso-N-acetyl-DL-penicillamine Chemical Structure

S-Nitroso-N-acetyl-DL-penicillamine Chemical Structure

CAS No. : 67776-06-1

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10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation[1][2][3][4].

In Vitro

S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO)[1].
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes[3].
S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes[3].

Cell Viability Assay[1]

Cell Line: Rat liver sinusoidal endothelial cells
Concentration: 2 mM, 5 mM, 10 mM
Incubation Time: 2 hours, 4 hours, 6 hours, 8 hours
Result: Exhibited cytotoxicity against cultivated endothelial cells.
In Vivo

SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [3H]-acetylcholine release in guinea-pig tracheal[4].

Clinical Trial
Molecular Weight

220.25

Formula

C₇H₁₂N₂O₄S

CAS No.

67776-06-1

SMILES

O=NSC(C)(C(C(O)=O)NC(C)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1135.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5403 mL 22.7015 mL 45.4030 mL
5 mM 0.9081 mL 4.5403 mL 9.0806 mL
10 mM 0.4540 mL 2.2701 mL 4.5403 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

S-Nitroso-N-acetyl-DL-penicillamineSNAPNO SynthaseNitric oxide synthasesNOSNOInhibitorinhibitorinhibit

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Product name:
S-Nitroso-N-acetyl-DL-penicillamine
Cat. No.:
HY-121526
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