country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P11811A

Copy Link Print Information

GUB10194 acetate

Customer Review

Based on 1 Customer Validation

GUB10194 acetate is a fully potent and selective GPR10 agonist with an EC₅₀ of 15 nM. GUB10194 acetate does not significantly affect body weight or food intake.

For research use only. We do not sell to patients.

Formula: C₈₅H₁₄₈N₂₄O₂₃·xC₂H₄O₂
Molecular Weight:1874.23 (free base)

Storage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

GUB10194 acetate Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

GUB10194 acetate is a fully potent and selective GPR10 agonist with an EC₅₀ of 15 nM. GUB10194 acetate does not significantly affect body weight or food intake^[1].

All Neuropeptide FF Receptor Isoforms :

In Vitro

GUB10194 (30 min) acetate acts as a full, GPR10-selective agonist in Chem-1 cells expressing GPR10 (EC₅₀ = 15 nM), with no activity detected in CHO-K1 cells expressing NPFF2R (EC₅₀ > 5000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GUB10194 (1250 nmol/kg; s.c.; twice daily) acetate does not produce significant body weight loss or food intake inhibition in diet-induced obese mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 5 weeks old at purchase, diet-induced obese)^[1]
Dosage:

1250 nmol/kg
Administration:

s.c.; twice daily
Result:

Did not significantly influence body weight or food intake during treatment or wash-out period.
Was detected in plasma samples collected 4 hours after the last dose on treatment day 6.

Chemical Information

Appearance Solid
Molecular Weight 1874.23 (free base)
Formula C₈₅H₁₄₈N₂₄O₂₃·xC₂H₄O₂
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N.CC(O)=O.[x]
Sequence

Ser-Arg-Gly-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-Arg-Pro-Val-Gly-Arg-Phe-NH2
Sequence Shortening

SRG-{Lys(AEEA-AEEA-γGlu-C18 diacid)}-RPVGRF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alexopoulou F, et al. Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect. Sci Rep. 2022;12(1):1696. Published 2022 Feb 1. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

GUB10194 acetate

All Neuropeptide FF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GUB10194 acetate Related Classifications

HY-P11811A Related Classifications