1. GPCR/G Protein
  2. GNRH Receptor
  3. Cetrorelix Acetate

Cetrorelix Acetate (Synonyms: SB-75 acetate)

Cat. No.: HY-P0009A Purity: 99.69%
Handling Instructions

Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.

For research use only. We do not sell to patients.

Cetrorelix Acetate Chemical Structure

Cetrorelix Acetate Chemical Structure

CAS No. : 145672-81-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 295 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 372 In-stock
Estimated Time of Arrival: December 31
50 mg USD 612 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cetrorelix Acetate:

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Description

Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM[1].

IC50 & Target

IC50: 1.21 nM GnRH[1].

In Vitro

Cetrorelix Acetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix Acetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells[2].

Clinical Trial
Molecular Weight

1491.09

Formula

C₇₂H₉₆ClN₁₇O₁₆

CAS No.

145672-81-7

Sequence

N-acetyl-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-Ser-Tyr-{Cit}-Leu-Arg-Pro-Ala-NH2

Sequence Shortening

Ac-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-SY-{Cit}-LRPA-NH2

SMILES

CC(O)=O.O=C(N(CCC1)[[email protected]@H]1C(N[[email protected]](C)C(N)=O)=O)[[email protected]](CCCNC(N)=N)NC([[email protected]](CC(C)C)NC([[email protected]@H](CCCNC(N)=O)NC([[email protected]@H](NC([[email protected]](CO)NC([[email protected]](NC([[email protected]](NC([[email protected]](NC(C)=O)CC2=CC3=CC=CC=C3C=C2)=O)CC4=CC=C(Cl)C=C4)=O)CC5=CN=CC=C5)=O)=O)CC6=CC=C(O)C=C6)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (33.53 mM; Need ultrasonic)

H2O : 2 mg/mL (1.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6707 mL 3.3533 mL 6.7065 mL
5 mM 0.1341 mL 0.6707 mL 1.3413 mL
10 mM 0.0671 mL 0.3353 mL 0.6707 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.69%

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Keywords:

CetrorelixSB-75SB75SB 75GNRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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Cetrorelix Acetate
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