2. GPCR/G Protein
  3. GnRH Receptor
  4. Cetrorelix

Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cetrorelix

Cetrorelix Chemical Structure

CAS No. : 120287-85-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Cetrorelix:

Cetrorelix Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cetrorelix

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
4.2 nM
Compound: 1 (Cetrorelix)
Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK293 cells
Antagonism of human GnHR receptor, determined in a reporter gene assay in HEK293 cells
[PMID: 11462984]
Clinical Trial
Molecular Weight

1431.04

Formula

C70H92ClN17O14
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (17.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6988 mL 3.4940 mL 6.9879 mL
5 mM 0.1398 mL 0.6988 mL 1.3976 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.71%

SDS (393 KB)

COA (249 KB) LCMS (101 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6988 mL 3.4940 mL 6.9879 mL 17.4698 mL
5 mM 0.1398 mL 0.6988 mL 1.3976 mL 3.4940 mL
10 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.7470 mL
15 mM 0.0466 mL 0.2329 mL 0.4659 mL 1.1647 mL
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Cetrorelix Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cetrorelix120287-85-6SB-75SB75SB 75GnRH ReceptorGonadotropin releasing hormone receptorGNRHRovarian stimulationcyclophosphamideovarian follicularInhibitorinhibitorinhibit

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