Cetrorelix-d10
Cetrorelix-d10 (SB-75-d10) is the d10-labeled Cetrorelix (HY-P0009). Cetrorelix is a competitive gonadotropin-releasing hormone receptor (GnRHR) antagonist with a Kd of 0.19 nM. Cetrorelix inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby suppressing the secretion of downstream sex steroids. Cetrorelix prevents ovulation, induces reversible reproductive shutdown and azoospermia, reduces ovarian fibrosis, improves superovulation outcomes, and inhibits chemotherapy-induced mitochondria-dependent apoptosis. Cetrorelix is applicable for fertility assistance research.
For research use only. We do not sell to patients.
- Formula: C70H82D10ClN17O14
- Molecular Weight:1441.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 120287-85-6
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Molecular Weight 1441.10
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Formula C70H82D10ClN17O14
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SMILES
OC1=CC=C(C[C@@H](C(N[C@@H](C(N[C@]([2H])(C(N[C@H](C(N2[C@H](C(N[C@@H](C(N)=O)C)=O)CCC2)=O)CCCNC(N)=N)=O)C([2H])(C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[2H])=O)CCCNC(N)=O)=O)NC([C@@H](NC([C@@H](CC3=CN=CC=C3)NC([C@@H](CC4=CC=C(Cl)C=C4)NC([C@@H](CC5=CC6=C(C=C5)C=CC=C6)NC(C)=O)=O)=O)=O)CO)=O)C=C1
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Synonyms
SB-75-d10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhao XJ, et al. GnRH antagonist cetrorelix inhibits mitochondria-dependent apoptosis triggered by chemotherapy in granulosa cells of rats. Gynecologic oncology. 2010 Jul;118(1):69-75. [Content Brief]
[2]. Kanda A, et al. Effect of Cetrorelix administration on ovarian stimulation in aged mice. Experimental animals. 2021 Feb 06;70(1):31-36. [Content Brief]
[3]. Reissmann T, et al. The LHRH antagonist cetrorelix: a review. Human reproduction update. 2000;6(4):322-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cetrorelix-d10 Related Classifications
HY-P0009S1 Related Classifications
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- Cetrorelix-d10
- SB-75-d10
- Isotope-Labeled Compounds
- GnRH Receptor
- Apoptosis
- cynomolgus monkeys
- pituitary cells
- gonadotropin-releasing hormone receptor
- Sprague-Dawley rats
- human granulosa cells
- luteinizing hormone
- rat mast cells
- epidermal growth factor
- follicle-stimulating hormone
- C57BL/6J mice
- Inhibitor
- inhibitor
- inhibit