1. GPCR/G Protein
  2. GNRH Receptor
  3. Alarelin Acetate

Alarelin Acetate (Synonyms: Alarelin)

Cat. No.: HY-17405 Purity: 99.61%
Handling Instructions

Alarelin acetate is a synthetic GnRH agonist.

For research use only. We do not sell to patients.

Alarelin Acetate Chemical Structure

Alarelin Acetate Chemical Structure

CAS No. : 79561-22-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 153 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 156 In-stock
Estimated Time of Arrival: December 31
100 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Description

Alarelin acetate is a synthetic GnRH agonist.

In Vitro

The cell viability in the presence of alarelin was significantly lower than that in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner[1]

In Vivo

Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could significantly enhance ratio of G1 phase and decrease ratio of S phase of GSMC of rats[1].

Molecular Weight

1287.42

Formula

C₆₀H₈₆N₁₆O₁₆

CAS No.

79561-22-1

SMILES

O=C(N[[email protected]@H](CO)C(N[[email protected]@H](CC1=CC=C(O)C=C1)C(N[[email protected]](C)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N2CCC[[email protected]]2C(NCC)=O)=O)=O)=O)=O)=O)[[email protected]@H](NC([[email protected]@H](NC([[email protected]@H](N3)CCC3=O)=O)CC4=CN=CN4)=O)CC5=CNC6=CC=CC=C65.CC(O)=O.CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 58 mg/mL (45.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7767 mL 3.8837 mL 7.7675 mL
5 mM 0.1553 mL 0.7767 mL 1.5535 mL
10 mM 0.0777 mL 0.3884 mL 0.7767 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Rats: Male Sprague-Dawley rats are divided into two groups. In Group I: Gastric acid secretion is measured in a chambered stomach. Briefly, the abdomen is incised, and both the stomach and duodemun are exposed and tied respectively; then 1.5 mL 0.9% sodium chloride (containing Alarelin, 2 μg/kg) is infused into the each chambered stomach. After 15, 30, 45, 60 min, the gastric juice is drew out of the chambered stomach and the pH is measured in the ABL-500 respectively. The control is infused saline instead of Alarelin. In Group II: After anaesthetized, 2 mL Alarelin (2 μg/kg) is administered into the tail vein. The control is injected the saline instead of Alarelin. Then, the stomach and duodenum are tied and infused 1.5 mL saline immediately. After 15, 30, 45, 60 min, the gastric juice is also drew out of the chambered stomach and the pH is measured in the ABL-500 respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

AlarelinGNRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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Alarelin Acetate
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