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  2. GNRH Receptor
  3. Goserelin acetate

Goserelin acetate (Synonyms: ICI-118630 acetate)

Cat. No.: HY-13673A Purity: 99.96%
Handling Instructions

Goserelin acetate (ICI 118630 acetate) is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).

For research use only. We do not sell to patients.

Goserelin acetate Chemical Structure

Goserelin acetate Chemical Structure

CAS No. : 145781-92-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 193 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 396 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Goserelin acetate (ICI 118630 acetate) is an injectable gonadotropin releasing hormone superagonist (GnRH agonist). IC50 value: Target: GnRH agonist Goserelin is used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty. It may also be used in the treatment of male-to-female transsexuals and is favoured above other anti-androgens in some countries, such as the UK. It is available as a 1-month depot and a long-acting 3-month depot. Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner.

Clinical Trial
Molecular Weight

1329.46

Formula

C₆₁H₈₈N₁₈O₁₆

CAS No.

145781-92-6

SMILES

O=C(N[[email protected]](C(N[[email protected]@H](CC1=CC=C(O)C=C1)C(N[[email protected]](COC(C)(C)C)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N2CCC[[email protected]]2C(NNC(N)=O)=O)=O)=O)=O)=O)=O)CO)[[email protected]@H](NC([[email protected]](CC3=CN=CN3)NC([[email protected]@H](N4)CCC4=O)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (21.06 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7522 mL 3.7609 mL 7.5219 mL
5 mM 0.1504 mL 0.7522 mL 1.5044 mL
10 mM 0.0752 mL 0.3761 mL 0.7522 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.56 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (1.56 mM); Clear solution; Need warming

*All of the co-solvents are provided by MCE.

Purity: 99.96%

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GoserelinICI-118630ICI118630ICI 118630GNRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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Product name:
Goserelin acetate
Cat. No.:
HY-13673A
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