1. GPCR/G Protein
    Apoptosis
  2. GnRH Receptor
    Apoptosis
  3. Goserelin

Goserelin (Synonyms: ICI 118630)

Cat. No.: HY-13673
Handling Instructions

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.

For research use only. We do not sell to patients.

Goserelin Chemical Structure

Goserelin Chemical Structure

CAS No. : 65807-02-5

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Description

Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

IC50 & Target

GnRH[1]

In Vitro

Goserelin (1 nM-1 mM; 48-72 hours) promots EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) influences EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.

Western Blot Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1μM , 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.

RT-PCR[1]

Cell Line: SKOV3-ip cells
Concentration: 100 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Expression of human apoptosis-related genes regulated
In Vivo

Goserelin (100 µg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
Dosage: 100 µg/mice
Administration: Subcutaneous injection, daily, for 19 days
Result: Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors
Clinical Trial
Molecular Weight

1269.41

Formula

C59H84N18O14

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Goserelin
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