GUB08248 acetate
Based on 1 Customer Validation
GUB08248 acetate is a full GPR10 agonist and a partial NPFF2R agonist, with EC50 values of 0.5 nM and 2.5 nM, respectively. GUB08248 acetate inhibits food intake and induces sustained weight loss. GUB08248 acetate can be used in obesity-related research.
For research use only. We do not sell to patients.
- Formula: C85H150N24O21·xC2H4O2
- Molecular Weight:1844.25 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GUB08248 (30 min) acetate acts as a potent dual full agonist of GPR10 and partial agonist of NPFF2R in Chem-1 cells expressing GPR10 and CHO-K1 cells expressing NPFF2R, with EC50 values of 0.5 nM and 2.5 nM, respectively[1].
GUB08248 (1 h) acetate potently activates wild-type NPFF2R in HEK293T cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 5 weeks old at purchase, diet-induced obese)[1]
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Dosage:1250 nmol/kg
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Administration:s.c.; twice daily
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Result:Induced significant body weight loss of 10.9% relative to baseline by day 7.
Sustained body weight loss of 13.5% relative to baseline by day 13.
Significantly suppressed total food intake during the 7-day treatment phase relative to vehicle controls.
Restored food intake to vehicle levels during the wash-out phase.
Was detected in plasma samples collected 4 hours after last dosing on treatment day 6.
Chemical Information
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Appearance Solid
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Molecular Weight 1844.25 (free base)
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Formula C85H150N24O21·xC2H4O2
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SMILES
CC(O)=O.O=C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)C(O)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N.[x]
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Sequence
Ser-Arg-Gly-{Lys(AEEA-AEEA-γGlu-C18)}-Arg-Pro-Val-Gly-Arg-Phe-NH2
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Sequence Shortening
SRG-Lys(AEEA-AEEA-γGlu-C18)-RPVGRF-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
[1]. Alexopoulou F, et al. Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect. Sci Rep. 2022;12(1):1696. Published 2022 Feb 1. [Content Brief]
[2]. Li X, et al. Molecular basis for cross-activation of NPFF2R by a short PrRP-related peptide. Acta Pharmacol Sin. Published online February 4, 2026. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GUB08248 acetate Related Classifications
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