Fsh receptor-binding inhibitor fragment(bi-10)
Based on 1 Customer Validation
FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries.
For research use only. We do not sell to patients.
- Purity : 99.19%
- CAS No.: 163973-98-6
- Formula: C42H67N13O19
- Molecular Weight:1058.06
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g[1]
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Dosage:10, 20, 30, 40 mg/kg
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Administration:Intramuscularly injection; once a day for five consecutive days
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Result:Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles.
High dose (40mg/kg) treatment blocked the follicle development of mice.
High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.
Chemical Information
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CAS No. 163973-98-6
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Appearance Solid
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Molecular Weight 1058.06
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Formula C42H67N13O19
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Color White to off-white
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Sequence
Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2
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Sequence Shortening
TENLEPNGEG-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (94.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9451 mL | 4.7256 mL | 9.4513 mL | 23.6281 mL |
| 5 mM | 0.1890 mL | 0.9451 mL | 1.8903 mL | 4.7256 mL | |
| 10 mM | 0.0945 mL | 0.4726 mL | 0.9451 mL | 2.3628 mL | |
| 15 mM | 0.0630 mL | 0.3150 mL | 0.6301 mL | 1.5752 mL | |
| 20 mM | 0.0473 mL | 0.2363 mL | 0.4726 mL | 1.1814 mL | |
| 25 mM | 0.0378 mL | 0.1890 mL | 0.3781 mL | 0.9451 mL | |
| 30 mM | 0.0315 mL | 0.1575 mL | 0.3150 mL | 0.7876 mL | |
| 40 mM | 0.0236 mL | 0.1181 mL | 0.2363 mL | 0.5907 mL | |
| 50 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4726 mL | |
| 60 mM | 0.0158 mL | 0.0788 mL | 0.1575 mL | 0.3938 mL | |
| 80 mM | 0.0118 mL | 0.0591 mL | 0.1181 mL | 0.2954 mL |
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