Fsh receptor-binding inhibitor fragment(bi-10)

Name: Fsh receptor-binding inhibitor fragment(bi-10)
Brand: MedChemExpress
SKU: HY-P4190
Rating: 4.5 (0 reviews)

Cat. No.: HY-P4190 Pureza: 99.19%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

FSH receptor-binding inhibitor fragment(bi-10) is a potent FSH antagonist. FSH receptor-binding inhibitor fragment(bi-10) blocks the binding of FSH to FSHR, and alteres FSH action at the receptor level. FSH receptor-binding inhibitor fragment(bi-10) results in the suppression of ovulation and causes follicular atresia of mice. FSH receptor-binding inhibitor fragment(bi-10) has the potential for utilizing to restrain the carcinogenesis of ovarian cancer by down-regulating overexpression of FSHR and ERβ in the ovaries.

Para uso exclusivo en investigación. No vendemos a pacientes.

Síntesis de péptidos personalizados

Fsh receptor-binding inhibitor fragment(bi-10) Estructura química

No. CAS : 163973-98-6

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

In Vivo

FSH receptor-binding inhibitor fragment(bi-10) (10, 20, 30, 40 mg/kg; Intramuscularly injection; once a day for five consecutive days) with high dose (30 mg/kg to 40 mg/kg) can suppress ovarian and follicular development, and attenuate expression levels of ERβ and FSHR mRNAs and proteins in the ovaries, additionally inhibit E2 production^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Prepuberty Kunming female mice of 21-days old and body weight of 22.3±1.52g^[1]
Dosage:	10, 20, 30, 40 mg/kg
Administration:	Intramuscularly injection; once a day for five consecutive days
Result:	Could attenuate FSH promoting effect on the follicular development, resulting in the poor maturation of ovarian follicles. High dose (40mg/kg) treatment blocked the follicle development of mice. High dose of FRBI (40mg/kg) treatment blocked the follicle development of mice.

Peso molecular

1058.06

Fòrmula

C₄₂H₆₇N₁₃O₁₉

No. CAS

163973-98-6

Appearance

Solid

Color

White to off-white

Sequence

Thr-Glu-Asn-Leu-Glu-Pro-Asn-Gly-Glu-Gly-NH2

Sequence Shortening

TENLEPNGEG-NH2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (94.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9451 mL	4.7256 mL	9.4513 mL
5 mM	0.1890 mL	0.9451 mL	1.8903 mL
10 mM	0.0945 mL	0.4726 mL	0.9451 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.19%

Select Batch:

Ficha de datos (270 KB) SDS (252 KB)

COA (243 KB) LCMS (95 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Gong Zhuandi, et al. FSH receptor binding inhibitor restrains follicular development and possibly attenuates carcinogenesis of ovarian cancer through down-regulating expression levels of FSHR and ERβ in normal ovarian tissues. Gene. 2018 Aug 20;668:174-181. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9451 mL	4.7256 mL	9.4513 mL	23.6281 mL
	5 mM	0.1890 mL	0.9451 mL	1.8903 mL	4.7256 mL
	10 mM	0.0945 mL	0.4726 mL	0.9451 mL	2.3628 mL
	15 mM	0.0630 mL	0.3150 mL	0.6301 mL	1.5752 mL
	20 mM	0.0473 mL	0.2363 mL	0.4726 mL	1.1814 mL
	25 mM	0.0378 mL	0.1890 mL	0.3781 mL	0.9451 mL
	30 mM	0.0315 mL	0.1575 mL	0.3150 mL	0.7876 mL
	40 mM	0.0236 mL	0.1181 mL	0.2363 mL	0.5907 mL
	50 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4726 mL
	60 mM	0.0158 mL	0.0788 mL	0.1575 mL	0.3938 mL
	80 mM	0.0118 mL	0.0591 mL	0.1181 mL	0.2954 mL