2. GPCR/G Protein
  3. GnRH Receptor
  4. Linzagolix

Linzagolix  (Synonyms: KLH-2109; OBE-2109)

Cat. No.: HY-109093 Purity: 99.81%
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Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research.

For research use only. We do not sell to patients.

Linzagolix Chemical Structure

Linzagolix Chemical Structure

CAS No. : 935283-04-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 145 In-stock
Solution
10 mM * 1 mL in DMSO USD 145 In-stock
Solid
1 mg USD 61 In-stock
5 mg USD 130 In-stock
10 mg USD 200 In-stock
50 mg USD 700 In-stock
100 mg USD 1120 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research[1].

Clinical Trial
Molecular Weight

508.42

Formula

C22H15F3N2O7S
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C(C(SC=C1NC(N2C3=C(F)C=C(OC)C(OCC4=C(C(F)=CC=C4OC)F)=C3)=O)=C1C2=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (245.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9669 mL 9.8344 mL 19.6688 mL
5 mM 0.3934 mL 1.9669 mL 3.9338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9669 mL 9.8344 mL 19.6688 mL 49.1719 mL
5 mM 0.3934 mL 1.9669 mL 3.9338 mL 9.8344 mL
10 mM 0.1967 mL 0.9834 mL 1.9669 mL 4.9172 mL
15 mM 0.1311 mL 0.6556 mL 1.3113 mL 3.2781 mL
20 mM 0.0983 mL 0.4917 mL 0.9834 mL 2.4586 mL
25 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.9669 mL
30 mM 0.0656 mL 0.3278 mL 0.6556 mL 1.6391 mL
40 mM 0.0492 mL 0.2459 mL 0.4917 mL 1.2293 mL
50 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9834 mL
60 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8195 mL
80 mM 0.0246 mL 0.1229 mL 0.2459 mL 0.6146 mL
100 mM 0.0197 mL 0.0983 mL 0.1967 mL 0.4917 mL
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Linzagolix Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linzagolix935283-04-8KLH-2109 OBE-2109KLH2109KLH 2109OBE2109OBE 2109OBE-2109GnRH ReceptorGonadotropin releasing hormone receptorGNRHRuterine fibroidsendometriosisadenomyosisInhibitorinhibitorinhibit

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