1. GPCR/G Protein
  2. GnRH Receptor
  3. Linzagolix

Linzagolix  (Synonyms: KLH-2109; OBE-2109)

Cat. No.: HY-109093 Purity: 99.68%
COA Handling Instructions

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research.

For research use only. We do not sell to patients.

Linzagolix Chemical Structure

Linzagolix Chemical Structure

CAS No. : 935283-04-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
USD 116 In-stock
Solution
10 mM * 1 mL in DMSO USD 116 In-stock
Solid
1 mg USD 45 In-stock
5 mg USD 104 In-stock
10 mg USD 160 In-stock
25 mg USD 344 In-stock
50 mg USD 560 In-stock
100 mg USD 896 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Linzagolix:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research[1][2][3].

In Vivo

Linzagolix (50 mg/kg) reduces cyst volume in a rat model of endometriosis[1].
Lindagolix reduces serum luteinizing hormone and testosterone levels in male rats and dogs with normal or BPH models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Endometriosis model rat[1]
Dosage: 50 mg/kg
Administration:
Result: Reduced cyst volume.
Clinical Trial
Molecular Weight

508.42

Formula

C22H15F3N2O7S

CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C(C(SC=C1NC(N2C3=C(F)C=C(OC)C(OCC4=C(C(F)=CC=C4OC)F)=C3)=O)=C1C2=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (245.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9669 mL 9.8344 mL 19.6688 mL
5 mM 0.3934 mL 1.9669 mL 3.9338 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9669 mL 9.8344 mL 19.6688 mL 49.1719 mL
5 mM 0.3934 mL 1.9669 mL 3.9338 mL 9.8344 mL
10 mM 0.1967 mL 0.9834 mL 1.9669 mL 4.9172 mL
15 mM 0.1311 mL 0.6556 mL 1.3113 mL 3.2781 mL
20 mM 0.0983 mL 0.4917 mL 0.9834 mL 2.4586 mL
25 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.9669 mL
30 mM 0.0656 mL 0.3278 mL 0.6556 mL 1.6391 mL
40 mM 0.0492 mL 0.2459 mL 0.4917 mL 1.2293 mL
50 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9834 mL
60 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8195 mL
80 mM 0.0246 mL 0.1229 mL 0.2459 mL 0.6146 mL
100 mM 0.0197 mL 0.0983 mL 0.1967 mL 0.4917 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Linzagolix
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