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BAY-899 

Cat. No.: HY-130248
Handling Instructions

BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels.

For research use only. We do not sell to patients.

BAY-899 Chemical Structure

BAY-899 Chemical Structure

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Description

BAY-899 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 185 nM and 46nM for hLH (human LH) and rLH (rat LH), respectively. BAY-899 can reduce sex hormone levels[1].

IC50 & Target

IC50: 185 nM (hLH) and 46nM (rLH)[1]

In Vivo

BAY-899 (oral; 12.5 mg/kg/day; for 8 days) shows an efficiency to reduce serum estradiol levels in intact female rats[1].
BAY-899 (iv of 0.5 mg/kg or po of 2 mg/kg) has a t1/2 of 11 hours and 12 hours for iv and po. And the Cmax is 0.97 kg/L and 0.24 kg/L for iv and po[1].

Animal Model: Intact female rats[1]
Dosage: 12.5 mg/kg
Administration: Oral; for 8 days
Result: Showed an efficiency to reduce serum estradiol levels.
Animal Model: Female and male Wistar rats[1]
Dosage: 0.5 mg/kg of iv or 2 mg/kg of po
Administration: Iv or po
Result: Has t1/2s of 11 hours and 12 hours for iv and po. And the Cmaxs are 0.97 kg/L and 0.24 kg/L for iv and po.
Molecular Weight

459.45

Formula

C₂₅H₁₉F₂N₅O₂

SMILES

O=C(N1[[email protected]@H](C2=CC=C(F)C=C2)C3=C(N=CC=C3)CC1)NC4=CN=C(OC5=CC=C(F)C=C5)N=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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BAY-899
Cat. No.:
HY-130248
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