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BAY-298 

Cat. No.: HY-130249
Handling Instructions

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels.

For research use only. We do not sell to patients.

BAY-298 Chemical Structure

BAY-298 Chemical Structure

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Description

BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels[1].

IC50 & Target

IC50: 185 nM (hLH), 46nM (rLH) and 78 nM (cLH)[1]

In Vivo

BAY-298 (oral; 4.5-72 mg/kg/day; for 8 days) dosedependently loweres serum estradiol levels in proestrus[1].
BAY-298 (iv of 0.5 mg/kg or po of 2 mg/kg) has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po[1].

Animal Model: Intact female rats[1]
Dosage: 4.5, 9, 18, 36, 72 mg/kg
Administration: Oral; for 8 days
Result: Dosedependently lowered serum estradiol levels in proestrus.
Animal Model: Female and male Wistar rats[1]
Dosage: 0.5 mg/kg of iv or 2 mg/kg of po
Administration: Iv or po
Result: Has t1/2s of 31 hours and 33 hours for iv and po. And the Cmaxs are 0.28 kg/L and 0.066 kg/L for iv and po.
Molecular Weight

473.93

Formula

C₂₇H₂₁ClFN₃O₂

SMILES

O=C(N1[[email protected]@H](C2=CC=C(Cl)C=C2)C3=C(N=CC=C3)CC1)NC4=CC=C(OC5=CC=C(F)C=C5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BAY-298BAY298BAY 298OthersInhibitorinhibitorinhibit

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BAY-298
Cat. No.:
HY-130249
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