1. GPCR/G Protein
  2. EBI2/GPR183
  3. ML401

ML401 

Cat. No.: HY-116814
Handling Instructions

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.

For research use only. We do not sell to patients.

ML401 Chemical Structure

ML401 Chemical Structure

CAS No. : 1597489-14-9

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Description

ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1].

IC50 & Target

IC50: 1.03 nM (EBI2)[1]

In Vitro

ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM)[1].

In Vivo

ML401 shows very good stability in both human plasma and mouse plasma[1].

Molecular Weight

419.74

Formula

C₂₀H₂₀BrClN₂O

CAS No.

1597489-14-9

SMILES

O=C(/C=C/C1=CC=C(C=C1)Br)N2CCN(CC2)CC3=CC=C(C=C3)Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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ML401
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